| 绞股蓝总皂甙抗大鼠海马结构缺血再灌注损伤的实验研究 |
| |
| 引用本文： | 王秋桂 胡松林. 绞股蓝总皂甙抗大鼠海马结构缺血再灌注损伤的实验研究[J]. 中国病理生理杂志, 1997, 13(5): 513-516 |
| |
| 作者姓名： | 王秋桂 胡松林 |
| |
| 作者单位： | 咸宁医学院神经组化研究室 |
| |
| 摘 要： | 探讨大鼠海马结构缺轿再灌注损伤机理及绞股蓝总皂甙抗缺血再灌注损伤的作用，结果：ＩＲ组海马组织中ＭＤＡ含量高于组（Ｐ〈０．０１），而ＳＯＤ含量低于ＳＯＣ组（Ｐ〈０．０１），差异非常显著：ＩＲ＋ＧＰ组海马组织中ＭＤＡ含量明显低于ＩＲ组（Ｐ〈０．０１），而ＳＯＣ含量明显高于ＩＲ组（Ｐ〈０．０１），ＩＲ组海马组织Ｎａ＾＋－Ｋ＾＋－ＡＴＰａｓｅ，Ｃａ＾２＋－ＡＴＰａｓｅ的活性明显低于ＳＯＣ组（Ｐ〈０．０１）
|
| 关 键 词： | 海马 绞股蓝总皂甙 脑缺血 再灌注损伤 |
Inhibitory effect of gynostemma pentaphyllum againt ischemia reperfusion damage of hippocampal struction in rat |
| |
| Abstract: | In order to investigate the mechanism of ischemia reperfusion (IR) injury of hippocampal structure and the protective effect of gynostemma pentaphyllum(GP) on the neuronal damage,tissue superoxide dismutase (SOD)activity,ATPase activity,malondialehyde(MDA) content and ultrastructure changes in the hippocampus were observed.The result showed that in comparing with ischemia reperfusion group,hippocampal SOD activity was higher(P<0.01).MDA content was lower(P<0.01)and ATPase activity was higher in the IR GP and sham operated control group.In addition,the neurous tissue damage observed under electron microscope also showed notable discrepancy.The result suggested that GP could increase SOD activity,reduce lipid peroxidation,reduce neuronal damage in the IR injury of hippocampal structure. |
| |
| Keywords: | |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
