| 镁对在体兔缺血—再灌心脏的电生理效应 |
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| 引用本文： | 朱俏萍,赖世忠.镁对在体兔缺血—再灌心脏的电生理效应[J].中国病理生理杂志,1997,13(3):282-285. |
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| 作者姓名： | 朱俏萍 赖世忠 |
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| 作者单位： | [1]解放军157医院心血管内科 [2]第一军医大学南方医院心血管内科 |
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| 摘 要： | 本实验通过结扎兔冠状动脉左室支复制动脉缺血－再灌注模型，应用心外膜接触电极记录单相动作电位，观察后除极电位在再灌注性心律失常中及镁离子的拮抗作用。结果表明，再灌性心律失常的５２．６％与早期后去极化有关。硫酸镁可终止及预防ＲＡ，对再灌中出现触发活动有抑制作用。
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| 关 键 词： | 镁 动作电位 心律失常 |
Effect of magnesium on electrophysiologic responses of ischemia -reperfusion in rabbit heart in vivo |
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| Zhu Qiao-Ping,Chen De -Zhao,Lai Shi -Zhong,Liu Yi-Li
PLA Hospital and Nan Fang Hospital. Guangzhou.Effect of magnesium on electrophysiologic responses of ischemia -reperfusion in rabbit heart in vivo[J].Chinese Journal of Pathophysiology,1997,13(3):282-285. |
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| Authors: | Zhu Qiao-Ping Chen De -Zhao Lai Shi -Zhong Liu Yi-Li
PLA Hospital and Nan Fang Hospital Guangzhou |
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| Abstract: | The left anterion descending (LAD) coronary artery occlusion -reperfusion model of rabbit heart was used to measure the monophasic action potentials (MAP) by contact electrode. The effects of after depolarization in the reperfusion arrhythmia and the antiarrhythmic effect of magnesium were observed. The results indicated that 52.6% (10/19) of reperfusion arrhythmia (RA) were associated with the early after depolarization (EAD). Magnesium could prevent and block RA, it had inhibitory effect on triggered activities during heart reperfusion. MAP amplitude were increased and A action potential duration were improved after magnesium sulphate infusion. These results suggested that magnesium had protective effects on electrophysioloy of ischemic - reperfusion heart in rabbit in |
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