| 丹参对急性缺血后再灌注心肌磷脂肌醇系统变化的影响 |
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| 引用本文： | 陶月玉,严玉兰.丹参对急性缺血后再灌注心肌磷脂肌醇系统变化的影响[J].中国病理生理杂志,1997,13(3):267-269. |
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| 作者姓名： | 陶月玉 严玉兰 |
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| 作者单位： | [1]南京海军414医院心内科 [2]南京海军神经生物学研究中心 |
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| 摘 要： | 本文首镒报道采用大鼠在体心肌缺血后再灌注模型观察丹参对急性短时间缺血后再灌注心肌磷脂肌醇代谢的影响。结果显示：急性缺血１０ｍｉｎ后灌注１０ｍｉｎ，心肌磷脂肌醇信息传递系统功能明显增强，其磷脂酰肌醇－４，５－二磷酸和肌醇－１，４，５－三磷酸水平显著高于非缺血对照组和缺血组；丹参能显著抑制急性缺血后再灌注心肌磷脂肌醇系统的高功能状态，其ＰＩＰ２和ＩＰ３水平明显低于缺血组和缺血再灌注组。
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| 关 键 词： | 丹参 心肌缺血 再灌注损伤 磷脂 肌醇 |
Effects of salvia miltiorrhizae on phosphainositides metabolism during acute myocardial ischemia - reperfusion in rat |
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| Tao Yue-Yu,Guo Song-Duo,Yan Yue-Lan,Lu You-Ming,Lu Bu-Feng
Navy No. Hospital,Nanjing.Effects of salvia miltiorrhizae on phosphainositides metabolism during acute myocardial ischemia - reperfusion in rat[J].Chinese Journal of Pathophysiology,1997,13(3):267-269. |
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| Authors: | Tao Yue-Yu Guo Song-Duo Yan Yue-Lan Lu You-Ming Lu Bu-Feng
Navy No Hospital Nanjing |
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| Abstract: | The effects of Salvia Miltiorrhizae on phosphainositides metabolism during acute myocardial ischemia - reperfusion in rats were studied. The results showed that the function of the phosphainositides signaling system of myocardium was enhanced in acute myocardial ischemia-reperfusion. Both of phosphatidylinositol - 4, 5 - biphosphate(PIP2) and inositol-1, 4, 5 - triphosphate (IP3) in reperfusing group were higher than that of non-ischemia control group and ischemic group(P<0.01, n = 7); The high function of the phosphainositide signaling system in reperfusing myocardium was remarkablely inhibited by Salvia Miltiorrhizae (2 g/kg body wt, ip), and the levels of PIP2 and IP3 were lower than that in reperfusing group and ischemic group(P<0.01, n = 7). |
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