喹硫平治疗神经梅毒伴发精神行为症状的临床观察

目的探讨喹硫平治疗神经梅毒伴有精神行为症状的临床疗效和安全性。方法 48例神经梅毒伴有精神行为症状患者使用喹硫平治疗6周。疗效指标为阳性与阴性症状量表（PANSS）和临床疗效总评量表-病情严重程度（CGI-SI）,采用副反应量表（TESS）评价其不良反应,在治疗前和治疗后第1、2、4和6周末时进行评估。结果治疗后患者的PANSS和CGI-SI评分均减少,差异具有统计学意义[治疗前和第6周时PANSS评分分别是（82·63±8·19）分;（47·21±3·34）分,t=18·4,P〈0·01）]。不良反应少且程度较轻,主要为嗜睡、便秘等。结论喹硫平能安全且有效改善神经梅毒伴发的精神行为症状,需要进一步的随机对照临床试验方能推广。

Clinical observation on Quetiapine in the treatment of behavioral and psychological symptoms of patients with neurosyphilis

Objective To research the effect and safety of quetiapine for behavioral and psychological symptoms of neurosyphilis.Methods Forty-eight patients with neurosyphilis companied with behavioral and psychological symptoms were treated with Quetiapine for6 weeks.The efficacy and side effects was assessed using PANSS,CGI-SI and TESS before and after1,2,4 and 6 weeks of the treatment.Results The PANSS and CGI-SI had decreased after administering Quetiapine.The difference had statistical significance [PANSS before and after 6w of treatment was（82·63±8·19）points,（47·21±3·34）points respectively.t=18·46,P 0·01）].There was less adverse effect.The main adverse events were somnolence adn constipation.Conclusion Quetiapine is safe and effective during the treatment of behavioral and psychological symptoms of neurosyphilis.But further randomized controlled trial is needed.