5-Azacytidine Is Insufficient For Cardiogenesis In Human Adipose-Derived Stem Cells |
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| Authors: | Wan Kamarul Zaman Wan Safwani Suzana Makpol Somasundaram Sathapan Kien Hui Chua |
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| Affiliation: | (1) Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia;(2) Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia;(3) Subang Jaya Medical Centre, Selangor, Malaysia |
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| Abstract: | Background Adipose tissue is a source of multipotent adult stem cells and it has the ability to differentiate into several types of cell lineages such as neuron cells, osteogenic cells and adipogenic cells. Several reports have shown adipose-derived stem cells (ASCs) have the ability to undergo cardiomyogenesis. Studies have shown 5-azacytidine can successfully drive stem cells such as bone marrow derived stem cells to differentiate into cardiomyogenic cells. Therefore, in this study, we investigated the effect 5-azacytidine on the cardiogenic ability of ASCs. |
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