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| 阿克他利固体脂质纳米粒的制备 | |
| 引用本文： | 周学锋,张娜,黄桂华,王淑芹. 阿克他利固体脂质纳米粒的制备[J]. 中国药业, 2006, 15(10): 30-31 |
| 作者姓名： | 周学锋 张娜 黄桂华 王淑芹 |
| 作者单位： | 1. 山东省青岛市中心医院,山东,青岛,266042 2. 山东大学药学院药剂教研室,山东,济南,250012 3. 山东省济南市天桥区疾病控制中心,山东,济南,250023 |
| 摘 要： | 目的以乳化蒸发一低温固化法制备阿克他利固体脂质纳米粒。方法在单因素考察的基础上以正交试验设计优化、筛选最佳处方和制备工艺。用透射电镜观察固体脂质纳米粒的形态，激光散射测定Zeta电位和粒度分布，高速离心法测定阿克他利固体脂质纳米粒的包封率。结果所制固体脂质纳米粒外观形态圆整，粒度分布为50～200am，平均粒径为120am，Zeta电位为一17．14mV，包封率为50．87％。结论阿克他利固体脂质纳米粒的制备，为开发阿克他利静脉注射被动靶向制剂奠定了试验基础。 |
| 关 键 词： | 阿克他利 固体脂质纳米粒 正交试验 包封率 |
| 文章编号： | 1006-4931(2006)10-0030-02 |
| 收稿时间： | 2005-09-01 |
| 修稿时间： | 2005-09-01 |
Preparation of Actarit Solid Lipid Nanoparticles |
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| Zhou Xuefeng,Zhang Na,Huang Guihua,Wang Shuqin. Preparation of Actarit Solid Lipid Nanoparticles[J]. China Pharmaceuticals, 2006, 15(10): 30-31 | |
| Authors: | Zhou Xuefeng Zhang Na Huang Guihua Wang Shuqin |
| Affiliation: | 1. Qingdao Central Hospital of Shandong Province, Qingdao, Shandong, China 266042; 2. Department of Pharmacy, College of Pharmacy, Shandong University, Jinan, Shandong, China 250012; 3. Tianqiao District Center of Diseaze Control and Prevention, Jinan City, Shandong Province, Jinan, Shandong, China 250023 |
| Abstract: | Objective To prepare actarit solid lipid nanoparticles(A-SLN)by solvent emulsification-evaporation method.Methods Based on the result of single-factor experiments,4 factors were selected to search the best formulation and the best preparation routes with orthogonal experiments.The diameters and the Zeta potential were measured.TEM was used to observe the particles shapes.Results The drug entrapment efficiency(EE%)was detected.The mean particle size was found to be 120 nm with a narrow particle distribution of polydispersity index.The Zeta potential of the A-SLN which was produced by the best formulation was-17.14 mV and the drug entrapment efficiency was 50.87%.Conclusion The preparation of A-SLN can be served as the basic experiment to prepare actarit target injections. |
| Keywords: | actarit solid liplid nanoparticle orthogonal experiment the drug entrapment efficiency |
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