Toxoplasmic myositis as a presenting manifestation of idiopathic CD4 lymphocytopenia |
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Authors: | Plonquet Anne Bassez Guillaume Authier François-Jérôme Dray Jean Marc Farcet Jean Pierre Gherardi Romain K |
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Affiliation: | Equipe Mixte 0011 INSERM/Université Paris XII Système neuromusculaire et inflammation, CHU Henri Mondor, Créteil, France. |
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Abstract: | Toxoplasma gondii encysts in skeletal muscle. Although only rarely found at muscle biopsy, this parasite has previously been regarded as a possible cause of polymyositis. We report a case of biopsy-proven toxoplasmic myositis in a non-HIV-infected patient that led to recognition of idiopathic CD4 lymphocytopenia (ICL), a rare condition typically associated with opportunistic infections. Interestingly, the CD25(+) subset that corresponds to the CD4(+) regulatory T cells controlling autoimmune processes was lacking. Steroid and antiprotozoal therapy led to recovery. |
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Keywords: | CD4+ regulatory T‐cells idiopathic CD4 lymphocytopenia polymyositis toxoplasmosis |
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