Galectin-3表达与乳腺癌进展、转移关系的研究

目的研究galectin-3表达与乳腺癌进展及淋巴结转移的关系。方法应用组织芯片技术和免疫组织化学方法对117例浸润性乳腺癌和41例乳腺良性病变（乳腺纤维腺瘤及乳腺小叶增生）的galectin-3表达进行检测。结果Galectin-3在乳腺癌和乳腺良性病变中的阳性率分别为87．61％（99／113）和29．73％（11／37），乳腺癌组galectin-3表达率明显高于乳腺良性病变组（P〈0．001）。乳腺癌中galectin-3阳性表达与淋巴结转移（P〈0．005）、肿瘤低分化（P〈0．05）、ER阴性（P〈0．05）及c-erbB-2阳性表达（P〈0．05）有关，但与TNM分期、患者年龄及PR、E—cadherin表达的关系尚无统计学意义。结论乳腺癌中galectin-3表达可能促进肿瘤演进，并可能增加患者发生淋巴结转移的风险。

Relationship between galectin-3 expression and progression and metastasis of breast cancer

Objective To explore the relationship between galectin-3 expression and progression and lymph node metastasis of breast cancer.Methods By tissue microarray technique and immunohistochemical method,galectin-3 expression of 117 invasive breast cancer cases and 41 benign breast lesion cases were studied.Results The positive rate of galectin-3 expression of the breast cancer group(87.61%,99/113) was significantly higher(P<0.001) than that of the benign breast lesions group(29.73%,11/37).In breast cancer,the galectin-3 positive expression was correlated with lymph node metastasis(P<0.005),higher histological grade(P<0.05),estrogen receptor(ER) negative expression(P<0.05) and c-erbB-2 positive expression(P<0.05).However,there was no significant association between galectin-3 expression and TNM stage,patient age and progesterone receptor(PR),and E-cadherin status.Conclusions Galectin-3 may play an important role in the progressive processes of human breast cancer and increase the risk of lymph node metastasis.