| 奥沙利铂联合氟尿嘧啶和亚叶酸钙治疗铂耐药复发卵巢癌初探 |
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| 引用本文： | 王祎晨,徐小仙,孙海燕. 奥沙利铂联合氟尿嘧啶和亚叶酸钙治疗铂耐药复发卵巢癌初探[J]. 临床合理用药杂志, 2012, 0(35): 27-28 |
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| 作者姓名： | 王祎晨 徐小仙 孙海燕 |
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| 作者单位： | 浙江省肿瘤医院 |
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| 摘 要： | 目的探讨奥沙利铂(L-OHP)联合氟尿嘧啶(5-FU)和亚叶酸钙(LV)治疗晚期复发性卵巢癌的临床效果。方法对6例铂耐药复发卵巢癌患者行L-OHP联合5-FU、LV方案化疗,每3周重复,观察其临床效果及毒副反应。结果疗效评定4例部分有效(PR),1例稳定(SD),1例进展(PD),毒副反应均不严重。结论奥沙利铂联合5-FU、LV治疗铂耐药复发卵巢癌有一定疗效,值得进一步研究。
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| 关 键 词： | 卵巢癌 铂耐药 奥沙利铂 氟尿嘧啶 |
Study of oxaliplatin plus 5-fluorouracil and leucovorin in the treatment of platinum-resistant recurrent ovarian cancer |
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| WANG Yi-chen,XU Xiao-xian,SUN Hai-yan. Study of oxaliplatin plus 5-fluorouracil and leucovorin in the treatment of platinum-resistant recurrent ovarian cancer[J]. Chinese Journal of Clinical Rational Drug Use, 2012, 0(35): 27-28 |
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| Authors: | WANG Yi-chen XU Xiao-xian SUN Hai-yan |
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| Affiliation: | .Department of Gynecological Oncology,Zhejiang Tumor Hospital,Hangzhou,Zhejiang 310022,China |
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| Abstract: | Objective To study the clinical efficacy of oxaliplatin plus 5-fluorouracil（5-FU） and leucovorin （LV）in the treatment of platinum-resistant recurrent advanced ovarian cancer patients.Methods 6 patients with platinum-resistant recurrent advanced ovarian cancer were given the chemotherapy of oxaliplatin plus 5-FU and LV every 3 weeks.The clinical effects and adverse reactions were observed.Results 4 patients achieved a partial response （PR）,1 patient had stable disease （SD） and 1 patient had progressive disease （PD）.The adverse reactions were not serious.Conclusion The chemotherapy of oxaliplatin plus 5-FU and LV shows a certain curative effect in the treatment of patients with platinum-resistant recurrent advanced ovarian cancer,which deserves further research. |
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| Keywords: | Ovarian neoplasms Oxaliplatin Fluorouracil |
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