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| H19基因研究进展 | |
| 引用本文： | 张小刚,安利国,郑晓飞.H19基因研究进展[J].军事医学科学院院刊,2011,35(6):469-472. |
| 作者姓名： | 张小刚 安利国 郑晓飞 |
| 作者单位： | 1. 山东师范大学,济南,250014;军事医学科学院放射与辐射医学研究所,北京,100850 2. 山东师范大学,济南,250014 3. 军事医学科学院放射与辐射医学研究所,北京,100850 |
| 基金项目： | 国家自然科学基金资助项目 |
| 摘 要： | H19基因编码一个2.3 kb的非编码RNA分子,其母系等位基因表达,父系印迹,在哺乳动物中呈现进化上的保守性,是最早被鉴定的印迹基因之一。近年发现H19外显子还生成一个小分子非编码RNA——miR-675。H19在胚胎发育、肿瘤发生等过程中发挥重要作用。本文就其印迹调节、功能以及与microRNA的关系等予以综述。 |
| 关 键 词： | RNA 微RNAs H19基因 Igf2基因 基因表达 基因组印迹 miR-675 染色体 胚胎发育 |
Current progress in research on H19 gene |
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| ZHANG Xiao-gang,AN Li-guo,ZHENG Xiao-fei.Current progress in research on H19 gene[J].Bulletin of the Academy of Military Medical Sciences,2011,35(6):469-472. | |
| Authors: | ZHANG Xiao-gang AN Li-guo ZHENG Xiao-fei |
| Institution: | ZHANG Xiao-gang1,2,AN Li-guo1,ZHENG Xiao-fei2(1.Shandong Normal University,Jinan 250014,China,2.Institute of Radiation Medicine,Academy of Military Medical Sciences,Beijing 100850,China) |
| Abstract: | The H19 gene encodes a 2.3 kb non-coding RNA which is maternally expressed,paternally imprinted and conserved on mammalian evolution.This gene is one of the first imprinted genes to be identified.Recently it was shown that a small non-coding RNA-miR-675 is produced from the exon of the H19 gene that plays an important role in embryonic development,tumorigenesis,etc.In this article,regulation of imprinting,function and relation with microRNA of the H19 gene are reviewed. |
| Keywords: | RNA miR-675 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |