前颞叶切除术后癫痫患者记忆功能的改变及影响因素的分析

目的:观察前颞叶切除术对癫痫患者记忆改变的作用,并分析影响因素.方法:48例癫痫患者行前颞叶切除术,术后随访1年.采用临床记忆量表,分别在术前l周、术后2周和术后6月进行3次测评.结果:随访1年内,Engle I级38例(79.1%),II级6例(12.5%),Ⅲ级3例(6.3%),IV级l例(2.1%).术后2周,患者的记忆功能有明显的减退;至术后6月,记忆功能又有所恢复,和术前1周水平相当.而有海马硬化者、优势半球侧手术者、术后疗效差者记忆功能下降较为明显.结论:前颞叶切除术后2周,癫痫患者记忆水平有所下降,其后又逐渐恢复.海马硬化、优势半球侧手术、术后疗效差是其可能的危险因素.

Memory function of change in patients with epilepsy after anterior temporal lobectomy and influencing factors

Objective: To observe the memory functional change in patients with epilepsy after anterior temporal lobectomy,and to analyze the influencing factors.Methods:48 patients with epilepsy undergoing anterior temporal lobectomy were enroll in this study.and followed up for 1 year.Clinical Memory Scale was used to assess the memory function at 1 week before operation,2nd week and the 6th month after the operation,respectively.Results: In the 1 year follow-up,38 patients were graded as Engle I,6 patients,as Engle II,3 patients,as Engle Ⅲ,and l patients as Engle IV. Two weeks after operation,the memory function in patients significantly reduced; six months after operation,the memory function resorted,to the same level as that 1 week before operation.And patients with hippocampal sclerosis,operation at dominant hemisphere side.and the poor prognosis had more noticeable memory function decline.Conclusion: The memory function decline at 2 weeks after anterior temporal lobectomy for patients with epilepsy,then restored gradually.Hippocampal sclerosis,operation at dominant hemisphere side,poor prognosis may be the risk factors.