黄芪注射液早期应用对新生儿缺氧缺血性脑病预后的影响

目的探讨黄芪注射液早期应用对缺氧缺血性脑病（H IE）患儿预后的影响。方法选择HIE 130例,按家长意见分为治疗组65例及对照组65例。治疗组在常规治疗基础上尽早加用中药黄芪注射液。恢复期两组均给予保护脑细胞、高压氧、针灸、功能训练。对两组患儿均进行随访。结果6、12、18个月龄时治疗组平均发育商（DQ）显著高于对照组（P〈0.05）,12个月龄后两组患儿DQ各能区得分均有提高,但治疗组明显高于对照组,两组比较差异有统计学意义（P〈0.05）。对照组后遗症发生率（26.67%）明显高于治疗组（7.60%）,差异有统计学意义（χ^2=4.410,P〈0.05）。结论HIE患者早期应用黄芪注射液治疗能改善其预后,降低脑瘫发生率,防止智能发育落后。

The influences of prognosis of early therapy of astragalus injection in neonates with hypoxic ischemic encephalopathy

Objective To explore the effect of early therapy of intravenous Astragalus on the prognosis of neonates with hypoxie ischemic encephalopathy （HIE）. Methods 130 neonates with HIE were selected and divided into treatment group （n =65） and control group （ n = 65 ） according to parents＇will. In treatment group, astragalus injection was added early on the basis of the routine treatment. During the recovery period, therapy for protecting brain cells, hyperbaric oxygen, acupuncture, and functional exercise were the same in the two groups. A follow-up was carried out in neonates in the two groups. Results Mean developmental quotients （DQ） of children in treatment group at 6,12 and 18 month of age were greatly higher than those in the control group （P〈0.05）. Each district scores of DQ was increased in children of 12 month of two groups, but the treatment group was significantly higher than control group （ X^2 = 4. 410, P 〈 0. 05 ）. Conclusion Early administration of Astragalus injection can improve their prognosis and reduce cerebral palsy and mental development behind of children with HIE.