首页 | 本学科首页   官方微博 | 高级检索  
     


Quantitative analysis of left ventricular strain using cardiac computed tomography
Authors:Sebastian J. Buss  Felix Schulz  Derliz Mereles  Waldemar Hosch  Christian Galuschky  Georg Schummers  Daniel Stapf  Nina Hofmann  Evangelos Giannitsis  Stefan E. Hardt  Hans-Ulrich Kauczor  Hugo A. Katus  Grigorios Korosoglou
Affiliation:1. Department of Cardiology, University of Heidelberg, 69120 Heidelberg, Germany;2. Department of Diagnostic and Interventional Radiology, University of Heidelberg, 69120 Heidelberg, Germany;3. TomTec Imaging Systems GmbH, Munich, Germany
Abstract:

Objectives

To investigate whether cardiac computed tomography (CCT) can determine left ventricular (LV) radial, circumferential and longitudinal myocardial deformation in comparison to two-dimensional echocardiography in patients with congestive heart failure.

Background

Echocardiography allows for accurate assessment of strain with high temporal resolution. A reduced strain is associated with a poor prognosis in cardiomyopathies. However, strain imaging is limited in patients with poor echogenic windows, so that, in selected cases, tomographic imaging techniques may be preferable for the evaluation of myocardial deformation.

Methods

Consecutive patients (n = 27) with congestive heart failure who underwent a clinically indicated ECG-gated contrast-enhanced 64-slice dual-source CCT for the evaluation of the cardiac veins prior to cardiac resynchronization therapy (CRT) were included. All patients underwent additional echocardiography. LV radial, circumferential and longitudinal strain and strain rates were analyzed in identical midventricular short axis, 4-, 2- and 3-chamber views for both modalities using the same prototype software algorithm (feature tracking). Time for analysis was assessed for both modalities.

Results

Close correlations were observed for both techniques regarding global strain (r = 0.93, r = 0.87 and r = 0.84 for radial, circumferential and longitudinal strain, respectively, p < 0.001 for all). Similar trends were observed for regional radial, longitudinal and circumferential strain (r = 0.88, r = 0.84 and r = 0.94, respectively, p < 0.001 for all). The number of non-diagnostic myocardial segments was significantly higher with echocardiography than with CCT (9.6% versus 1.9%, p < 0.001). In addition, the required time for complete quantitative strain analysis was significantly shorter for CCT compared to echocardiography (877 ± 119 s per patient versus 1105 ± 258 s per patient, p < 0.001).

Conclusion

Quantitative assessment of LV strain is feasible using CCT. This technique may represent a valuable alternative for the assessment of myocardial deformation in selected patients with poor echogenic windows and general contraindications for magnetic resonance imaging.
Keywords:2D/3D/4D, two-dimensional/three-dimensional/four-dimensional   2D-CCT, two-dimensional strain cardiac computed tomography   2D-Echo, two-dimensional strain echocardiography   CRT, cardiac resynchronization therapy   CCT, cardiac computed tomography   EF, ejection fraction   ESV, end-systolic volume   EDV, end-diastolic volume   LV, left ventricle
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号