"In vitro" effect of interleukin-1 beta on human glioma cell lines: regulation of cell proliferation and IL-6 production. |
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| Authors: | S Cinque J Willems S Depraetere L Vermeire M Joniau |
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| Affiliation: | Laboratory of Biochemistry IRC, K. U. Leuven Campus Kortrijk, Belgium. |
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| Abstract: | The human glioma cell lines U251 and HP591 were chosen as "in vitro" models for functional astrocytes. When cultured in the presence of IL-1 beta these cell lines demonstrated a marked increase in interleukin-6 production and in [3H]-thymidine uptake. The addition of dbcAMP could mimic the first effect of IL-1 beta but at the same time suppressed cell proliferation. These results suggest that IL-1 beta possibly exerts one of its biological effects (IL-6 synthesis) by means of the cyclic AMP pathway. |
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