线粒体与衰老

衰老是一种复杂的病理生理现象 ,主要表现为机体各种功能的下降。大量研究结果表明 ,衰老的发展过程与线粒体功能异常有密切关系。在衰老过程中 ,线粒体生物学发生变化 ,线粒体产生自由基和自由基对线粒体的损伤对衰老的发展起到促进作用 ;线粒体DNA突变和线粒体对细胞死亡进程的调控与衰老的进程有密切关系。本文主要对以上内容作一综述。

Mitochondria and aging

Aging is a complex pathological and physiological phenomenon characterized by the decline of many functions in human. Several lines of experimentation showed that the defect of the mitochondria function is one of the driving forces for the progress of aging. During the development of aging, the alteration of biology of mitochondria, the accumulation of the generation of "free radical"in mitochondria, the mutation in mitochondria genomes and the control of the progress of death by mitochondria were suggested to be a number of novel mechanisms for mitochondria in aging. The experiment data focused on the role of mitochondria in aging are reviewed.