Role of technetium 99m methoxyisobutylisonitrile single photon emission tomography in the evaluation of thrombolysis in acute myocardial infarction before and after admission to hospital |
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| Authors: | Marc Faraggi Bernard Bok |
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| Affiliation: | (1) Departments of Nuclear Medicine and Cardiology of Hospitals Beaujon (Clichy), A. Beclere (Clamart), X. Bichat (Paris), Lariboisiere (Paris), and the Emergency Mobile Units, Service Mobile d'Urgence et de Reanimation des Hauts de Seine (SMUR 92), and Service Medical d'Urgence de la Brigade des Sapeurs Pompiers de Paris (SMU-BSPP), France;(2) Present address: Nuclear Medecine Department, Hospital Beaujon, 100 Bvd du Général Leclerc, F-92110 Clichy, France |
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| Abstract: | To investigate initial perfusion status in acute myocardial infarction, methoxyisobutylisonitrile (MIBI) was administered by the rescue physicians. Thirty-nine patients received the radiopharmaceutical at home or upon arrival at the hospital. Diagnosis was confirmed in 30 patients, and 19 emergency thrombolyses were performed. Initial single photon emission tomography (SPET) analysis was constantly abnormal in confirmed myocardial infarction sometimes before direct electrocardiographic signs. MIBI-SPET was normal in non-coronary syndromes. MIBI uptake improved after thrombolysis (P < 0.001) but also after heparin therapy (P < 0.05). SPET improvement demonstrated myocardial salvage earlier than wall motion studies. MIBI administration at the patient's home allowed very early perfusion imaging when thrombolysis was performed at home. MIBI-SPET has the potential use of comparing thrombolytic agents or at home versus in hospital thrombolysis.for the Multicenter Study Group  Etude MIBI (EMIBI)Members of the EMIBI Group |
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| Keywords: | Methoxyisobutylisonitrile single photon emission tomography Acute myocardial infarction At home thrombolysis Myocardial salvage |
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