| Expression of HLA class Ⅰ and Ⅱ on peripheral blood lymphocytes in HBV infection |
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| 引用本文： | Wang CX,Wang JF,Liu M,Zou X,Yu XP,Yang XJ,Zheng GX. Expression of HLA class Ⅰ and Ⅱ on peripheral blood lymphocytes in HBV infection[J]. 中华医学杂志(英文版), 2006, 119(9): 753-756 |
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| 作者姓名： | Wang CX Wang JF Liu M Zou X Yu XP Yang XJ Zheng GX |
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| 作者单位： | [1]Department of Laboratory Medicine, Qilu Hospital, Shandong University, Jinan 250012, China [2]Department of Virology, Shandong University, Jinan 250012, China |
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| 基金项目： | This study was supported by a grant from the Science and Technology Department of Shandong Province （No. 2002BB 1CJA8）. |
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| 摘 要： | Persistent hepatitis B virus （HBV） infection is the most important reason for chronic hepatitis B,hepatic cirrhosis, and hepatocellular carcinoma. T lymphocytes, including CD4^＋ and CD8^＋ T cells, are major composition of host cellular immunity. Furthermore, CD8^＋ cells play a primary role in host immune reaction of anti-tumor and anti-infection. It has been confirmed that HBV infection leads to disorder of cellular immune function in patients, especially disorder in regulative function of T lymphocyte subgroups and cytokine. It has been paid more attention to the expression of HLA class I on hepatocytes infected by HBV and tumor cells, but less to the expression of HLA class I on peripheral blood lymphocytes in the past. In this study, we evaluated the expression of HLA class I and II on peripheral blood lymphocytes in patients with chronic hepatitis B, hepatic cirrhosis, and hepatocellular carcinoma and tried to provide new thought for the mechanism of disorder of celluar immunity.
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| 关 键 词： | 淋巴细胞 外周血 乙型肝炎病毒 病毒感染 |
| 收稿时间： | 2005-12-05 |
Expression of HLA class I and II on peripheral blood lymphocytes in HBV infection |
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| Wang Chuan-xin,Wang Jin-feng,Liu Min,Zou Xiong,Yu Xiu-ping,Yang Xiao-jing,Zheng Gui-xi. Expression of HLA class I and II on peripheral blood lymphocytes in HBV infection[J]. Chinese medical journal, 2006, 119(9): 753-756 |
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| Authors: | Wang Chuan-xin Wang Jin-feng Liu Min Zou Xiong Yu Xiu-ping Yang Xiao-jing Zheng Gui-xi |
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| Affiliation: | 1. Department of Laboratory Medicine, Qilu Hospital, Shandong University, Jinan 250012, China
2. Department of Virology, Shandong University, Jinan 250012,China |
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| Abstract: | |
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| Keywords: | HLA antigens hepatitis B virus hepatitis B, chronic fiver cirrhosis carcinoma, hepatocellular |
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