| 视网膜静脉阻塞和Eales病患者玻璃体内皮生长因子含量测定 |
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| 引用本文： | 杨萍,张惠蓉. 视网膜静脉阻塞和Eales病患者玻璃体内皮生长因子含量测定[J]. 中华眼底病杂志, 1997, 13(3): 171-173 |
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| 作者姓名： | 杨萍 张惠蓉 |
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| 作者单位： | 北京医科大学第三临床医院眼科 |
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| 基金项目： | 博士学科点专项科研基金,国家自然科学基金 |
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| 摘 要： | 目的：了解血管内皮生长因子(vascular endothelial growth factor，VEGF)在视网膜血管增殖性疾病患者玻璃体中的含量。方法：采用酶联免疫吸附实验(enzyme linked immunosorbent assay，ELISA)测定伴有新生血管的视网膜静脉阻塞(retinal vein occlusion，RVO)和视网膜静脉周围炎(Eales病)患者玻璃体VEGF含量。结果：RVO患者(7例)和Eales病患者(7例)玻璃体VEGF含量分别为(4.67士3.38)ng/ml和(1.79土0.44)ng/ml，是正常人(0.35土0.15)ng/ml的13倍和5倍(P<0.01)。结论；RVO和Eales病患者玻璃体VEGF水平明显升高，提示VEGF可能参与其眼内新生血管增殖机制。（中华眼底病杂志，1997，13：171-173）
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| 关 键 词： | 视网膜静脉闭塞／血液 内皮.血管 内皮生长因子／血液 视网膜静脉 静脉炎／血液 |
| 收稿时间： | 1996-12-02 |
| 修稿时间： | 1997-02-17 |
LEVELS OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN THE VITREOUS OF PATIENTS WITH RETINAL VEIN OCCLUSION AND EALES'' DISEASE |
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| Yang Ping,Zhang Huirong. . LEVELS OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN THE VITREOUS OF PATIENTS WITH RETINAL VEIN OCCLUSION AND EALES'' DISEASE[J]. Chinese Journal of Ocular Fundus Diseases, 1997, 13(3): 171-173 |
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| Authors: | Yang Ping Zhang Huirong. |
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| Affiliation: | department of Ophthalmology,Third Hospital,Beijing Medical University,Beijing 100083,China |
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| Abstract: | PURPOSE:To investigate the content of vascular endothelial growth factor (VEGF)in vitreous of patients with retinal vascula'r proliferative diseases. METHODS:The concentration of VEGF in undiluted vitreous samples from patients with retina vein occlusion (RVO) (n=7),Eales disease (n=7)and controls (n=7) was measured by enzyme linked immunosorbent assay (EL1SA). RESULTS:The levels of vitreous VEGF were significantly higher 13 folds in patients with RVO(4.67±3.38)ng/ml and 5 folds in patients with Eales disease(1.79±0.44)ng/ml than in controls (0.35±0.15)ng/ml separately(P＜0. 01). CONCLUSIONS:VEGF might play a part in mediating the neovascularization of retinal vascular diseases.（Chin J Ocul Fundus Dis,1997,13:171-173） |
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| Keywords: | Retinal vein occlusion/blood Endotholial grouth factors/blood Endothelium vascular Retinal vein phlebitis/blood |
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