视网膜静脉阻塞和Eales病患者玻璃体内皮生长因子含量测定

目的：了解血管内皮生长因子(vascular endothelial growth factor，VEGF)在视网膜血管增殖性疾病患者玻璃体中的含量。 方法：采用酶联免疫吸附实验(enzyme linked immunosorbent assay，ELISA)测定伴有新生血管的视网膜静脉阻塞(retinal vein occlusion，RVO)和视网膜静脉周围炎(Eales病)患者玻璃体VEGF含量。 结果：RVO患者(7例)和Eales病患者(7例)玻璃体VEGF含量分别为(4.67士3.38)ng/ml和(1.79土0.44)ng/ml，是正常人(0.35土0.15)ng/ml的13倍和5倍(P<0.01)。 结论；RVO和Eales病患者玻璃体VEGF水平明显升高，提示VEGF可能参与其眼内新生血管增殖机制。 （中华眼底病杂志，1997，13：171-173）

LEVELS OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN THE VITREOUS OF PATIENTS WITH RETINAL VEIN OCCLUSION AND EALES' DISEASE

PURPOSE:To investigate the content of vascular endothelial growth factor (VEGF)in vitreous of patients with retinal vascula'r proliferative diseases. METHODS:The concentration of VEGF in undiluted vitreous samples from patients with retina vein occlusion (RVO) (n=7),Eales disease (n=7)and controls (n=7) was measured by enzyme linked immunosorbent assay (EL1SA). RESULTS:The levels of vitreous VEGF were significantly higher 13 folds in patients with RVO(4.67±3.38)ng/ml and 5 folds in patients with Eales disease(1.79±0.44)ng/ml than in controls (0.35±0.15)ng/ml separately(P＜0. 01). CONCLUSIONS:VEGF might play a part in mediating the neovascularization of retinal vascular diseases. （Chin J Ocul Fundus Dis,1997,13:171-173）