| 药理试验中动物间和动物与人体间的等效剂量换算 |
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| 引用本文： | 黄继汉,黄晓晖,陈志扬,郑青山,孙瑞元. 药理试验中动物间和动物与人体间的等效剂量换算[J]. 中国临床药理学与治疗学, 2004, 9(9): 1069-1072 |
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| 作者姓名： | 黄继汉 黄晓晖 陈志扬 郑青山 孙瑞元 |
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| 作者单位： | 安徽省药物临床评价中心,皖南医学院弋矶山医院,芜湖,241001,安徽 |
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| 摘 要： | 不同动物的剂量换算，在基础药理和Ⅰ期临床研究中具有现实指导意义，本文将动物体型系数及其标准体重引入公式，通过查表，可方便地估算出不同动物间和动物与人体间的等效剂量。
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| 关 键 词： | 剂量换算 等效剂量 Ⅰ期临床试验 健康志愿者 |
| 文章编号： | 1009-2501(2004)09-1069-04 |
| 修稿时间： | 2004-08-16 |
Dose conversion among different animals and healthy volunteers in pharmacological study |
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| HUANG Ji-Han,HUANG Xiao-Hui,CHEN Zhi-Yang,ZHENG Qing-Shan,SUN Rui-Yuan Anhui Provincial Center for Drug Clinical Evaluation,Yijishan Hospital of Wannan Medical College,Wuhu ,Anhui,China. Dose conversion among different animals and healthy volunteers in pharmacological study[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(9): 1069-1072 |
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| Authors: | HUANG Ji-Han HUANG Xiao-Hui CHEN Zhi-Yang ZHENG Qing-Shan SUN Rui-Yuan Anhui Provincial Center for Drug Clinical Evaluation Yijishan Hospital of Wannan Medical College Wuhu Anhui China |
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| Affiliation: | HUANG Ji-Han,HUANG Xiao-Hui,CHEN Zhi-Yang,ZHENG Qing-Shan,SUN Rui-Yuan Anhui Provincial Center for Drug Clinical Evaluation,Yijishan Hospital of Wannan Medical College,Wuhu 241001,Anhui,China |
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| Abstract: | In order to obtain equivalent dose, a dose conversion was important among different animals and healthy volunteers in preclinical pharmacology and I phase clinical trials. Body coefficient and standard weight were introduced into the formula to estimate the equivalent dose in this paper. |
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| Keywords: | dose conversion I phase clinical trial human equivalent dose healthy volunteers |
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