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Antiretroviral therapy abrogates association between arginase activity and HIV disease severity |
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| Authors: | T.E. Cloke A. Hailu G.P. Taylor P. Kropf |
| Affiliation: | a Department of Immunology, Faculty of Medicine, Imperial College London, Norfolk Place, London W2 1PG, UK b Department of Microbiology, Parasitology and Immunology, University of Addis Ababa, Addis Ababa, Ethiopia c Department of Hematology and Oncology, University of Mainz, Mainz, Germany d Department of Genito-Urinary Medicine and Communicable Diseases, Imperial College London, London, UK |
| Abstract: | Arginase-induced L-arginine deprivation is emerging as a key mechanism for the downregulation of immune responses. We hypothesised that arginase activity increases with disease severity in HIV-seropositive patients. Our results show that peripheral blood mononuclear cells (PBMCs) from 23 HIV-seropositive patients with low CD4+ T cell counts (≤350 cells/μl) expressed significantly more arginase compared with 21 patients with high CD4+ T cell counts. Furthermore, we found a significant association between the two principal prognostic markers used to monitor HIV disease (CD4+ T cell count and plasma viral load) and PBMC arginase activity in antiretroviral therapy naïve patients but not in patients undergoing therapy. |
| Keywords: | HIV Immune response T cells CD4 cell count Arginase L-arginine |
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