年轻腹型肥胖者的QT离散度及其与颈动脉粥样硬化关系研究

目的 探讨年轻单纯性腹型肥胖者的QT离散度(QTd、QTcd)及与颈动脉粥样硬化的关系.方法 选择18～35岁单纯性腹型肥胖者38例(肥胖组)及年龄、肥胖与之相匹配的正常体重者34例(对照组),分别测量体质指数(BMI)、腰臀比(WHR)、QTd、QTcd值;超声检测颈动脉内中膜厚度(IMT)及有否斑块.结果 肥胖组血压、体质指数、腰臀比、QTd、QTcd均增大,与对照组比较差异有统计学意义(均P<0.05);QT离散度>50 ms者发生IMT异常的危险度高于QT离散度<50 nm者(OR=7.0,P<0.05).结论 年轻人单纯性腹型肥胖者QT离散度大于正常参考值,颈动脉内中膜异常;QT离散度>50ms时其发生动脉粥样硬化的危险性增加;提示QT离散度可作为预测心血管病变的一项参考指标.

Study on the relationship between QT dispersion in youth with central obesity and carotid atherosclerosis.

Objective To explore the relationship between the QT dispersion in simple central obesity youth and carotid atherosclerosis. Methods 38 patients with simple central obesity (obesity group) aged from 18 to 35 years, and 34 normal weight healthy control subjects (control group), age-matched were chosen. The blood pres-sure(BP) ,body mass index(BMI) ,waist-hip ratio(WHR) ,QTd,QTcd,plus the ultrasound examination of the inti-ma-media thickness(IMT) of carotid were measured and plaques on the patients' carotid artery were detected. Re-sults Comparing to the control group,BP,BMI,WHR,QTd,QTcd were larger in the obesity group with significant difference (P < 0.05) ; When QT dispersion was > 50 ms, the risk of IMT was higher than that when QT dispersion was < 50 ms (OR = 7.0,P < 0.05). Condnsion In the youth who are simple central obesity, their QT disper-sions are over the normal reference value, intima-media thickness are abnormal; the risk of IMT is higher when QT dispersion is > 50 ms; suggesting that QT dispersion can be one of reference index for forecasting the cardiovascular disease.