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| 56例患者肾移植术后他克莫司治疗窗浓度范围再探讨 | |
| 引用本文： | 王守春,韩丽萍,司凯英,栾杰,杨爱淑. 56例患者肾移植术后他克莫司治疗窗浓度范围再探讨[J]. 中国药房, 2005, 16(23): 1802-1803 |
| 作者姓名： | 王守春 韩丽萍 司凯英 栾杰 杨爱淑 |
| 作者单位： | 1. 黑龙江大庆龙南医院,大庆市,163453 2. 广州军区广州总医院,广州市,510010 3. 哈药集团中药二厂,哈尔滨市,150018 |
| 摘 要： | 目的:探讨适合中国人的肾移植术后他克莫司(FK506)治疗窗浓度范围。方法:采用微粒子酶免疫法测定56例肾移植术后患者口服FK506后12h的全血谷浓度,并观察排斥反应及肾毒性反应的发生情况。结果:肾移植术后FK506的推荐治疗窗浓度范围0mo~1mo为9~14μg/L,2mo~3mo为8~12μg/L,4mo~6mo为6~10μg/L,7mo~12mo为4~6μg/L。结论:在上述治疗窗浓度范围内,既能达到满意的免疫抑制效果,又能减少排斥反应和肾毒性反应的发生。 |
| 关 键 词： | 肾移植 他克莫司 治疗窗浓度范围 |
| 文章编号： | 1001-0408（2005）23-1802-02 |
| 收稿时间： | 2005-01-25 |
| 修稿时间： | 2005-07-18 |
Therapeutic Window Concentration of Tacrolimus: Survey of 56 Cases of Renal Transplant Recipients |
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| WANG Shouchun,HAN Liping,SI Kaiying,LUAN Jie,YANG Aishu. Therapeutic Window Concentration of Tacrolimus: Survey of 56 Cases of Renal Transplant Recipients[J]. China Pharmacy, 2005, 16(23): 1802-1803 | |
| Authors: | WANG Shouchun HAN Liping SI Kaiying LUAN Jie YANG Aishu |
| Affiliation: | Daqing Longnan Hospital of Heilongiiang Province, Daqing 163453, China;Guangzhou General Hospital of Guangzhou Military Command, Guanzhou 510010, China;The Second Traditional Chinese Medicinal Factory of Harbin Pharmaceutical Group, Haerbin 150018, China |
| Abstract: | OBJECTIVE: To explore the therapeutic window concentration of tacrolimus(FK506) suitable for Chinese renal transplant recipients. METHODS: The whole blood valley concentration level in 56 renal transplant recipients 12h after oral administration with FK506 was determined by MEIA (Microparticle Enzyme Immunization). The rejections and the renal toxic reaction were observed as well. RESULTS: The recommended therapeutic window concentration of FK506 for Chinese renal transplant recipients were the following: 9～14μg/L during the first month; 8～12μg/L during the second to the third month; 6～10μg/L during the fourth to the sixth month; 4～6μg/L during the seventh to the twelfth month. CONCLUSION: FK506 has a satisfactory immune suppression effect while reducing incidences of rejections and renal toxic reactions if used within the above therapeutic window concentration. |
| Keywords: | Renal transplantation Tacrolimus Therapeutic window concentration |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |