| 5-HT3受体拮抗剂盐酸阿扎司琼的合成 |
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| 引用本文： | 5-HT3受体拮抗剂盐酸阿扎司琼的合成[J]. 中国药科大学学报, 2003, (3): 20-21. |
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| 作者姓名： | 罗小川 陈国华 徐昌盛 |
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| 作者单位： | 中国药科大学药化教研室,南京,210009 |
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| 摘 要： | 目的：改进5-HT3受体拮抗剂盐酸阿扎司琼的合成工艺。方法：以5-氯-2-羟基苯甲酸甲酯为原料，经硝化、还原等九步反应合成。结果：合成了目标化合物，总收率为40％，其结构经IR，^1HNMR和MS确证。结论：合成路线及工艺较适合于工业化生产。
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| 关 键 词： | 5－HT3受体拮抗剂 盐酸阿扎司琼 合成 |
| 文章编号： | 1000-5048(2003)03-0214-02 |
| 修稿时间： | 2002-08-21 |
Synthesis of the 5-HT3 Receptor Antagonist Azasetron Hydrochloride |
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| Synthesis of the 5-HT3 Receptor Antagonist Azasetron Hydrochloride[J]. Journal of China Pharmaceutical University, 2003, (3): 20-21. |
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| Authors: | LUO Xiao-Chuan CHEN Guo-Hu XU Chang-Sheng |
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| Affiliation: | LUO Xiao-Chuan,CHEN Guo-Hua,XU Chang-Sheng Department of Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009,China |
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| Abstract: | AIM:The purpose is to develop the general process for the synthesis of 5-HT 3 receptor antagonist Azasetron Hydrochloride. METHOD: It was synthesized from methyl 5-chloro-2-hydroxyl benzoic acid via nine-step reaction with nitration,reduction,etc. RESULT: The title compound was obtained with 40% overall yield. The structure was confirmed by IR, 1 HNMR and MS. CONCLUSION:Some improvements for the synthesis of Azasetron Hydrochloride were made. |
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| Keywords: | 5-HT 3 receptor antagonist Azasetron hydrochloride Synthesis |
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