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| 模拟失重大鼠下丘脑不同部位的Fos和GFAP表达 | |
| 引用本文： | 宿长军,饶志仁,张立藩.模拟失重大鼠下丘脑不同部位的Fos和GFAP表达[J].第四军医大学学报,2001,22(14):1268-1271. |
| 作者姓名： | 宿长军 饶志仁 张立藩 |
| 作者单位： | 1. 第四军医大学唐都医院神经内科, 2. 第四军医大学全军神经科学研究所, 3. 第四军医大学航空航天医学系航空航天生理学教研室 |
| 摘 要： | 目的 了解长期模拟失重状态下大鼠下丘脑功能活动状态。方法 用Fos和胶质原纤维酸性蛋白（GFAP）的ABC法，分别检测4周模拟失重大鼠下丘脑神经元和星形胶质细胞（AS）的变化。结果 二表达仅见于室旁核尤其大细胞部、视上核和视交叉上核，而其它部位未见表达；AS胞体变大、突起增粗增长。结论 下丘脑这些核团参与了对长期失重的反应，且可能与加压素分泌增加有关。 |
| 关 键 词： | 下丘脑 基因 Fos 神经胶质原纤维酸性蛋白 失重 |
| 文章编号： | 1000-2790(2001)14-1268-04 |
| 修稿时间： | 2000年7月13日 |
Fos and GFAP expression in different parts of hypothalamus in simulated weightlessness in rats |
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| SU Chang Jun ,RAO Zhi Ren ,ZHANG Li Fan.Fos and GFAP expression in different parts of hypothalamus in simulated weightlessness in rats[J].Journal of the Fourth Military Medical University,2001,22(14):1268-1271. | |
| Authors: | SU Chang Jun RAO Zhi Ren ZHANG Li Fan |
| Institution: | SU Chang Jun 1,RAO Zhi Ren 2,ZHANG Li Fan 3 1Department of Neurology,Tangdu Hospital,Xi'an 710038,China,2Institute of Neuroscience of Chinese PLA,3Department of Aerospace Physiology,Faculty of Aerospace Medicine,Fourth M |
| Abstract: | AIM To research the functions of rat hypothalamus under long term simulated weightlessness condition. METHODS By using anti Fos and anti GFAP immunohistochemical ABC methods, we observed changes of hypothalamus neurons and astrocytes in 4 wk simulated rats. RESULTS Expressions of Fos and GFAP positive cells were only found in paravetricular nuclei of the hypothalamus, especially in mango cellular part, supraoptic nuclei and suprachiasmatic nuclei, with negative reaction in other areas. The reactive astrocytes were featured with hypertrophy of the cell body and cytoplasmic processes. CONCLUSION These nuclei in hypothalamus may participate in the reaction to long term weightlessness, and probably be associated with increased secretion of vasopressure. |
| Keywords: | hypothalamus gene Fos glial fibrillary acidic protein weightlessness simulation |
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