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Vaccination against Human Influenza A/H3N2 Virus Prevents the Induction of Heterosubtypic Immunity against Lethal Infection with Avian Influenza A/H5N1 Virus
Authors:Rogier Bodewes   Joost H. C. M. Kreijtz   Chantal Baas   Martina M. Geelhoed-Mieras   Gerrie de Mutsert   Geert van Amerongen   Judith M. A. van den Brand   Ron A. M. Fouchier   Albert D. M. E. Osterhaus     Guus F. Rimmelzwaan
Abstract:Annual vaccination against seasonal influenza viruses is recommended for certain individuals that have a high risk for complications resulting from infection with these viruses. Recently it was recommended in a number of countries including the USA to vaccinate all healthy children between 6 and 59 months of age as well. However, vaccination of immunologically naïve subjects against seasonal influenza may prevent the induction of heterosubtypic immunity against potentially pandemic strains of an alternative subtype, otherwise induced by infection with the seasonal strains.
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