Pancreatic-type hyperamylasemia in end-stage renal disease |
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| Authors: | Toshie Araki MD Masatoshi Ueda MD Kazuhisa Taketa MD Kiyowo Kosaka MD |
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| Affiliation: | (1) Department of Medicine, Shigei Medical Research Hospital, Okayama, Japan;(2) Health Research Center, Kagawa University, Japan |
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| Abstract: | Pancreatic-type isoamylase (P-type) and salivary-type isoamylase (S-type) activities were determined by the wheat protein inhibitor method in 29 patients with end-stage renal disease and in 38 healthy volunteers. Serum levels of total amylase (322±43 units/liter) and P-type (212±39 units/liter) in ESRD were significantly higher than those of controls (total: 142±7 units/liter,P<0.01; P-type: 52±4 units/liter,P<0.01). There was no significant difference between S-type activities in ESRD (110±16 units/liter) and in controls (90±6 units/liter). The ratios of amylase clearance to creatinine clearance (Cam/Ccr) and S-type clearance to creatinine clearance (Cs-amy/Ccr) rose significantly in ESRD(Cam/Ccr: 5.7±0.6%; Cs-amy/Ccr: 4.3±0.55%) compared to controls (Cam/Ccr: 3.2±0.24%,P<0.01; Cs-amy/Ccr: 2.1±0.17%,P<0.01). The ratio of P-type clearance to creatinine clearance (Cp-amy/Ccr) revealed no significant difference between ESRD (5.5±0.54%) and controls (5.6±0.42%). The renal excretion of P-type appeared to be more impaired than that of S-type in ESRD. |
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| Keywords: | end-stage renal disease amylase isozyme amylase-creatinine clearance ratio |
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