抗生殖免疫抗体与女性不孕的关系

分析免疫性因素与女性不孕的关系。方法：本实验用ＥＬＩＳＡ方法检测年龄在２５－３５岁，不孕史两年以上原发不孕女３９０人，继发不孕妇女２９２人血清中抗精子抗（ＡＳＡｂ）。结果：原发不孕组ＡＳＡｂ阳性为２２．５６％，ＡＥＭＡ，ＡＥＭＡｂ１６．４１％，ａｏｖａＢ１４．８７，ＡｈＣＧＡｂ１４．３５％，ＡＣＰＡｂ１２．８５％；继发不 组ＡＳＡｂ阳性率１８．４９％，ＡＥＭＡｂ２５％，ＡＯＶＡｂ２．２０％，，ＡＨ

THE RELATIONSHIP BETWEEN THE ANTI-REPRODUCTIVE ANTIBODIES AND FEMALE INFERTILITY

The purpose of the research was to investigate the relationship between the female in fertile and anti reproductive antibodies.The sera of 390 primary and 292 secondary infertile women,25~35 years old,were detected sera antisperm antibody(ASAb),antiendometrium antibody(AEMAb),antiovary antibody(AOVAb),anti human chorionic gonadotropin antibody(AhCGAb),anticardiolipin antibody(ACPAb) with ELISA.The results showed that ASAb positive rate was 22 56%,AEMAb 16 41%,AOVAb 14 87%,AhCGAb 14 35%,ACPAb 12 85% in primary infertile group;the ASAb positive rate was 18 49%,AEMAb 25%,AOVAb 20 20%,AhCGAb 22 26%,ACPAb 18 83% in the secondary group.The statistical analysis showed that the positive rates of AEMAb,AhCGAb and ACPAb in secondary group were higher than those in primary group( P <0 05).But the positive rates of ASAb and AOVAb were no significant difference between two groups( P >0 05).Anti reproductive antibodies can interfere the ovum mature,ovulation,fertilization,fertilied ovum embeding,fetal development and mature for resulting in the decrease of female infertile capability.Because the productions of AEMAb,AhCGAb and ACPAb have related with the gregnancy,abortion and endometritis,so the positive rates of AEMAb,AhCGAb and ACPAb in secondary group were higher than those in primary group.The detection of the anti reproductive antibodies will provide the evidences for the diagnosis and cure of female infertility.