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氧氟沙星序贯疗法治疗细菌性感染
引用本文:李光辉,张婴元,吴卫红,吴培澄,汪复.氧氟沙星序贯疗法治疗细菌性感染[J].中国新药与临床杂志,1996(5).
作者姓名:李光辉  张婴元  吴卫红  吴培澄  汪复
作者单位:上海医科大学抗生素研究所
摘    要:目的:评价氧氟沙星静脉和口服序贯疗法治疗细菌性感染的有效性、安全性和可行性。方法:45例重症呼吸道、尿路感染病人,男性21例,女性24例;年龄49±s18a。先静脉滴注氧氟沙星200mg,q12h。呼吸道感染疗程为6.0±2,0d;尿路感染为4.0±1.0d.继以口服氧氟沙星200~300mg,bid。呼吸道与尿路感染的疗程分别为7.0±2.0d和6.0±2.0d.结果:临床有效率84%,细菌清除率86%。不良反应发生率13%。氧氟沙星对肠杆菌科等革兰阴性杆菌的抗菌活性优于氨苄西林、头孢唑林和庆大霉素,与环丙沙星、哌拉西林、头孢哌酮相仿。结论:氧氟沙星静脉与口服序贯疗法治疗细菌性感染效果好且安全。

关 键 词:氧氟沙星,细菌感染,临床试验,序贯疗法,口腔投药,静脉输注

Sequential therapy of ofloxacin on bacterial infections
LI Guang-Hui,ZhANG Ying-Yuan, WU Wei-Hong, WU Pei-Cheng,WANG FU.Sequential therapy of ofloxacin on bacterial infections[J].Chinese Journal of New Drugs and Clinical Remedies,1996(5).
Authors:LI Guang-Hui  ZhANG Ying-Yuan  WU Wei-Hong  WU Pei-Cheng  WANG FU
Abstract:AIM:To evaluate the efficacy,safety and possibility of the sequential therapy with intravenou and oral form of ofloxacin in patients with bacterial infections. METHODS:Forty-five patients of respiratory and urinary infections(M 21,F 24,age 49±s 18 a) were initially treated with ofloxacin 200 mg,iv,q 12h,the duration for RTI (respiratory tract infections) was 6.0±2.0 d and UTI(urinary tract infections) 4.0±1.0d,then followed by oral administration of ofloxacin 200~300 mg, bid, the durations for RTI and UTI were 7.0±2.0d and 6.0±2.0 d respectively. RESULTS:The total clinical effective and bacterial eradication rates were 84% and 86% respectively. Adverse reactions occurred in 13% of the patients. Result of MIC showed that the antibacterial activities of ofloxacin for Enterobacteriaceae and other Gram-negative organism were higher than those of ampicillin,cefazolin,and gentamicin,similar to those of ciprofloxacin,piperacillin and cefoperazon. CONCLUSION:Sequential therapy of ofloxacin intravenously and orally is effective and safe in patients with bacterial infections.
Keywords:ofloxacin  bacterial infections  clinical trials  sequential therapy  oral administration  intravenous infusions  
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