氧氟沙星序贯疗法治疗细菌性感染

目的：评价氧氟沙星静脉和口服序贯疗法治疗细菌性感染的有效性、安全性和可行性。方法：４５例重症呼吸道、尿路感染病人，男性２１例，女性２４例；年龄４９±ｓ１８ａ。先静脉滴注氧氟沙星２００ｍｇ，ｑ１２ｈ。呼吸道感染疗程为６．０±２，０ｄ；尿路感染为４．０±１．０ｄ．继以口服氧氟沙星２００～３００ｍｇ，ｂｉｄ。呼吸道与尿路感染的疗程分别为７．０±２．０ｄ和６．０±２．０ｄ．结果：临床有效率８４％，细菌清除率８６％。不良反应发生率１３％。氧氟沙星对肠杆菌科等革兰阴性杆菌的抗菌活性优于氨苄西林、头孢唑林和庆大霉素，与环丙沙星、哌拉西林、头孢哌酮相仿。结论：氧氟沙星静脉与口服序贯疗法治疗细菌性感染效果好且安全。

Sequential therapy of ofloxacin on bacterial infections

AIM:To evaluate the efficacy,safety and possibility of the sequential therapy with intravenou and oral form of ofloxacin in patients with bacterial infections. METHODS:Forty-five patients of respiratory and urinary infections(M 21,F 24,age 49±s 18 a) were initially treated with ofloxacin 200 mg,iv,q 12h,the duration for RTI (respiratory tract infections) was 6.0±2.0 d and UTI(urinary tract infections) 4.0±1.0d,then followed by oral administration of ofloxacin 200～300 mg, bid, the durations for RTI and UTI were 7.0±2.0d and 6.0±2.0 d respectively. RESULTS:The total clinical effective and bacterial eradication rates were 84% and 86% respectively. Adverse reactions occurred in 13% of the patients. Result of MIC showed that the antibacterial activities of ofloxacin for Enterobacteriaceae and other Gram-negative organism were higher than those of ampicillin,cefazolin,and gentamicin,similar to those of ciprofloxacin,piperacillin and cefoperazon. CONCLUSION:Sequential therapy of ofloxacin intravenously and orally is effective and safe in patients with bacterial infections.