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Maternal high-fat diet: effects on offspring bone structure

Authors:	S A Lanham C Roberts T Hollingworth R Sreekumar M M Elahi F R Cagampang M A Hanson R O C Oreffo

Institution:	(1) Bone and Joint Research Group, Developmental Origins of Health and Disease Division, Institute of Developmental Sciences, University of Southampton School of Medicine, Southampton, SO16 6YD, UK;(2) Maternal, Fetal, and Neonatal Physiology Group, Developmental Origins of Health and Disease Division, Institute of Developmental Sciences, University of Southampton School of Medicine, Southampton, SO16 6YD, UK;(3) Bone and Joint Research Group, MP887, Institute of Developmental Sciences, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK

Abstract:	Summary Peak bone mass is believed to partly be programmed in utero. Mouse dams and offspring were given a high-fat diet and offspring studied as adults. Female offspring from high-fat dams exhibited altered trabecular structure indicative of in utero programming. In utero nutrition has consequences in later life.

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