| 霉酚酸酯联合CsA和短程MTX预防非亲缘异基因骨髓移植的急性GVHD |
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| 引用本文： | 黄河 林茂芳 孟海涛 钱文斌 金洁 黄健 罗依. 霉酚酸酯联合CsA和短程MTX预防非亲缘异基因骨髓移植的急性GVHD[J]. 中华血液学杂志, 2001, 22(2): 76-78 |
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| 作者姓名： | 黄河 林茂芳 孟海涛 钱文斌 金洁 黄健 罗依 |
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| 作者单位： | 黄河（310003 杭州，浙江大学医学院附属第一医院血液科） 林茂芳（310003 杭州，浙江大学医学院附属第一医院血液科） 孟海涛（310003 杭州，浙江大学医学院附属第一医院血液科） 钱文斌（310003 杭州，浙江大学医学院附属第一医院血液科） 金洁（310003 杭州，浙江大学医学院附属第一医院血液科） 黄健（310003 杭州，浙江大学医学院附属第一医院血液科） 罗依（310003 杭州，浙江大学医学院附属第一医院血液科） |
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| 基金项目： | 浙江省科技厅重大资助项目(1103058)；浙江省医药卫生重点科技项目(2000ZD001) |
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| 摘 要： | 目的 评价霉酚酸酯（MMF）联合环孢菌素A（CsA）和短程甲氨蝶呤(MTX)预防非亲缘异基因骨髓移植中急性移植物抗宿主病（aGVHD）的有效性和安全性。方法 12例患者非亲缘异基因骨髓移植当天始联合应用MMF（骁悉胶囊）1.0g/d,CsA 3 mg
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| 关 键 词： | 霉酚酸酯 环孢菌素 骨髓移植 移植物抗宿主病 药物疗法 白血病 |
| 修稿时间： | 2000-04-27 |
Combination of mycophenolate mofetil with cyclosporine A and methotrexate as acu te GVHD prophylaxis after unrelated donor allogeneic bone marrow transplantation |
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| HUANG He,LIN Maofang,MENG Haitao. Combination of mycophenolate mofetil with cyclosporine A and methotrexate as acu te GVHD prophylaxis after unrelated donor allogeneic bone marrow transplantation[J]. Chinese Journal of Hematology, 2001, 22(2): 76-78 |
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| Authors: | HUANG He LIN Maofang MENG Haitao |
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| Affiliation: | Department of Hematology, Th e First Affiliated Hospital, Medical College of Zhejiang University, |
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| Abstract: | OBJECTIVE: To evaluate the efficacy and safety of mycophenolate mofetil (MMF) in combination with cyclosporine A (CsA) and methotrexate (MTX) for prevention of acute graft versus host disease (GVHD) after unrelated donor allogeneic bone marrow transplantation (allo-BMT). METHOD: Twelve cases of unrelated donor allo-BMT were evaluated in a single center trial. The acute GVHD was prevented with 1 g MMF daily in addition to CsA 3 mg x kg(-1) x (-1) and MTX 10 - 15 mg at post BMT day1, day3, day6 and day11. RESULTS: Acute GVHD was found in one case (Grade IV) at the seventh day and two cases (Grade II) at the tenth day and seventeenth day after BMT. These patients were treated with a combination of MMF, methyprednisolone and CsA. The common adverse hematologic events of MMF was leukopenia. CONCLUSION: The preliminary study showed that MMF could be used effectively and safely for prevention of acute GVHD in unrelated donor allo-BMT. |
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| Keywords: | Mycophenolate mofetil Cyclosporine Bone marrow transplantation Graft vs host disease |
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