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Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation and its relationship to aflatoxin B1-DNA adducts and p53 mutation in hepatocellular carcinoma
Authors:Zhang Yu-Jing  Chen Yu  Ahsan Habibul  Lunn Ruth M  Lee Po-Huang  Chen Chien-Jen  Santella Regina M
Affiliation:Departments of Environmental Health Sciences and Epidemiology, Mailman School of Public Health, Columbia University, 700 West 168th Street, New York, NY 10032, USA.
Abstract:
Keywords:epigenetic changes  hypermethylation  hepatocellular carcinoma  CpG island  O6‐methylguanine‐DNA methyltransferase
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