| 乙型肝炎病毒表面抗原变异的检测 |
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| 引用本文： | 龙厚玉,王思望,严有望. 乙型肝炎病毒表面抗原变异的检测[J]. 国际流行病学传染病学杂志, 2006, 33(4): 271-274 |
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| 作者姓名： | 龙厚玉 王思望 严有望 |
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| 作者单位： | 1. 434000,湖北省荆州市卫生监督局卫生监督科
2. 434000,湖州省荆州市荆州区卫生局 |
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| 摘 要： | HBV可因免疫或治疗的选择压力而出现变异,HBsAg变异株可在有中和抗体存在时增殖,而野毒株则会下降到不能检测的水平。HBsAg变异株在有些免疫学试验中呈假阴性,了解HBsAg变异株在免疫学试验中的反应性对建立适宜检测HBsAg的方法是很重要的。
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| 关 键 词： | HBV HBsAg 变异 检测 |
| 收稿时间： | 2006-03-09 |
| 修稿时间： | 2006-03-09 |
Detection of hepatitis B surface antigen mutants |
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| LONG Hou-yu,WANG Si-wang,YAN You-wang. Detection of hepatitis B surface antigen mutants[J]. International Journal of Epidemiology and Infectious Disease, 2006, 33(4): 271-274 |
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| Authors: | LONG Hou-yu WANG Si-wang YAN You-wang |
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| Affiliation: | Jingzhou Health Bureau, Jingzhou 434000, China |
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| Abstract: | Hepatitis B viral mutants can emerge in patients as a result of selection pressure from either immune response or treatment options. Mutations of HBsAg allow mutant virus to propagate in the presence of a neutralizing immune response, while wild-type virus is reduced to undetectable levels. HBsAg mutants present as false-negative results in some immunoassays. An understanding of immunoassay reactivity with HBsAg mutants is important to establishing an appropriate testing method for hepatitis B virus mutants. |
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| Keywords: | HBV HBsAg Mutant Detection |
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