Visual Results Following Cobalt Plaque Radiotherapy for Posterior Uveal Melanomas |
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Authors: | Alan F. Cruess James J. Augsburger Jerry A. Shields Larry A. Donoso Jonathan Amsel |
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Affiliation: | 2. Department of Epidemiology, Division of Research, Wills Eye Hospital, Thomas Jefferson University, Philadelphia |
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Abstract: | Visual results of cobalt plaque radiotherapy on the eyes of 77 patients with posterior uveal melanoma in one eye and pretreatment visual acuity of 20/25 or better in both eyes were analyzed using actuarial methods. The study demonstrated that eyes receiving a radiation dose in excess of 5,000 rad to the fovea and/or optic disc commonly lose a substantial amount of vision within 2 to 3 years. It also showed that eyes treated by cobalt plaque radiotherapy for a large posterior uveal melanoma are more likely to suffer profound visual loss than those treated for a medium or small melanoma. The predominant cause of severe visual loss in these patients appeared to be foveal radiation retinopathy. |
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Keywords: | cobalt plaque radiotherapy posterior uveal melanoma radiation retinopathy |
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