Role of intracellular Ca2+ on histamine release from rat peritoneal mast cells. |
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| Authors: | M Takei M Ueno K Endo |
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| Affiliation: | Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan. |
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| Abstract: | The benzoic acid derivative 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate hydrochloride (TMB-8) strongly inhibited histamine release from rat peritoneal mast cells induced by various secretagogues. TMB-8 also inhibited Ca2+ mobilization from intracellar Ca2+ stores. However, histamine release induced by compound 48/80 (condensation product of N-methyl-p-methoxy-phenethylamine and formaldehyde) was not affected by TMB-8. These results indicate that Ca2+ mobilization is necessary to elicit the release of histamine from mast cells. |
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