两种方法治疗耐多药肺结核疗效比较 |
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作者单位: | 广东省惠州市结核病防治所内科 广东惠州516008(黄慧忠,黄琳),广东省惠州市中心人民医院内科 广东惠州516001(吴勇) |
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摘 要: | 目的评价含司帕沙星化疗方案对耐多药结核病的临床应用价值。方法将80例MDR-TB患者随机分为两组各40例,治疗组用司帕沙星0.2g每晚口服;对照组氧氟沙星0.2g,3次/d。化疗方案:治疗组3SPL2ZPTh(E)/9SPL2Th;对照组3OL2ZPTh(E)/9OL2Th。比较治疗3个月、12个月的痰菌阴转率、X线胸片变化、药物不良反应及复发率。结果治疗组3个月痰菌阴转率(75.0%)高于对照组(45.0%()P<0.05),两组满疗程阴转率分别为90.0%、70.0%,满疗程X线病灶吸收率分别为90.0%、60.0%,空洞闭合率分别为85.7%、50.0%,均有显著性差异(P<0.05);80例随访2年复发率分别0%、20.0%(P<0.05)。两组皆无严重不良反应。结论SPLX对MDR-TB近期临床疗效显著,具有剂量小、疗程短、2年复发率低的优点。
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关 键 词: | 肺结核 药物疗法 司帕沙星 氧氟沙星 |
Comparison of Curative Effect for Multi-drug Resistant Pulmonary Tuberculosis by Two Methods |
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Authors: | HUANG Huizhong Wu Yong HUANG Lin |
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Institution: | HUANG Huizhong1 Wu Yong2 HUANG Lin1 1.Department of Medicine,Hui Zhou Municipal Institute of Tuberculosis Control and Prevention,Hui Zhou 516008, 2.Department of Medicine,Huizhou Central People's Hospital,Huizhou 516001 |
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Abstract: | Objective To evaluate the clinical curative effect of Sparfloxacin in the treatment of multi-drug resistant pulmonary tuberculosis.Methods 80 MDR-TB patients were randomly divided into two groups. SPLX0.2/qn was used in the treatment group and loxacin 0.2/tid and other anti-TB drugs(TH.Z.PAS etc)were used in the control group. The therapy plans were 3 SpL2ZPTh(E)/9SPL2Th for treatment group and 3OL2ZPTh (E)/9OL2Th for control group respectively. The sputum negative conversion rates,X-ray changing and drug side effect were compared in three and twelve month after treatment,and recurrence rate was observed for 2 years(n=39). Results The sputum negative conversion rates in treatment group was higher than that in control group(75.0% and 45.0%)in 3rd month; Sputum negative conversion rate,focal absorption rate and closure rate of cavities of treatment group in 12th month (90.%,90.0% and 85.0%) were higher than those of control group(70.0%,60.0% and 50.0%)(P<0.05). The recurrence rate in treatment group (0%)was lower than that in Control group (20.0%)(P<0.05) and no severe adverse reactions were found in two groups. Conclusion There are significant clinical curative effects to cure MDR-TB by SPLX with low dosage,short course of treatment and low recurrence rate. |
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Keywords: | Pulmonary tuberculosis Pharmacotherapy Sparfloxacin Ofloxacin |
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