Body mass index and biliary tract disease: A systematic review and meta-analysis of prospective studies |
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| Institution: | 1. Department of Food and Nutrition, Sookmyung Women''s University, Seoul 140-742, Republic of Korea;2. Division of Cancer Prevention, National Cancer Control Institute, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeounggi-do 410-769, Republic of Korea;3. Department of Food and Nutrition, Kyung Hee University, Seoul 130-701, Republic of Korea;1. Dept. of Health Promotion, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Israel;2. Preventive Medicine Branch, Medical Corps, Israel Defense Force, Israel;3. Hebrew University-Hadassah Braun School of Public Health and Community Medicine, Ein Kerem, Jerusalem, Israel;4. The Health Systems Management Program, Department of Management, Bar Ilan University, Israel;5. School of Public Health, University of Haifa, Israel |
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| Abstract: | ObjectiveTo evaluate the association between body mass index (BMI, kg/m2) and incidence of biliary tract disease.MethodsWe performed a systematic review and a meta-analysis of prospective studies by searching the database of PubMed and EMBASE published up to December 31, 2013. Outcome of interest was disease of biliary tract system (gallbladder, extrahepatic bile duct and Ampullar of Vater). We used a random-effects model to combine the study-specific relative risks (RRs) and 95% confidence intervals (95% CIs) from 22 prospective studies. We examined whether BMI was associated with a higher risk of biliary tract disease in a combined analysis.ResultsThe positive association was stronger for non-cancer biliary tract disease than biliary tract cancer; combined RRs (95% CIs) comparing the top with bottom categories were 1.40 (1.15–1.65) for biliary tract cancer and 2.75 (2.35–3.15) for non-cancer biliary tract disease (P for difference < 0.001). For non-cancer biliary tract disease, combined RRs (95% CIs) comparing the top with bottom categories were 3.21 (2.48–3.93) for women and 2.01 (1.66–2.37) for men (P for difference = 0.04).ConclusionObesity is associated with higher risks of biliary tract cancer and, to a greater extent, non-cancer biliary tract disease. |
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