国内外超说明书用药的文献计量分析

目的:对国内外超说明书用药主题文献进行计量分析。方法:计算机检索中国知网、万方数据、维普网、PubMed、Embase、Web of Science 于1991年1月(国外)或2007年1月(国内)起至2018年12月发表的超说明书用药相关文献。对纳入的国内及国外文献的基本情况(包括发文量分布、发文杂志分布)、文章合著(包括核心研究者、研究内容)、关键词共现进行分析总结。结果:共检索到国内文献1647篇、国外文献4418篇,其中有效文献国内1 570篇、国外4 238篇。近十年,国内外文献发文量呈上升趋势,2017年国内外发文量最多(国内355篇,国外465篇)。国内外发文量最多的杂志分别是《中国药房》(105篇)、European Journal ofClinical Pharmacology(51篇)。国内外核心研究者分别是李幼平、de la Torre JC。国内研究的内容有超说明书用药政策、儿童超说明书用药现状、眼科超说明书用药、中成药超说明书用药等;国外研究的内容有抗病毒药物超说明书用药、特殊人群(儿童、酒精依赖患者等)超说明书用药等。国内外文献关键词排名前3的分别是超说明书用药、合理用药、药品说明书和human、off-label use、article。结论:国内外超说明书用药的研究逐年递增,各团队积极开展跨地区合作,通过文献计量的方法可助力学者拓宽研究方向,追踪研究热点,选择投稿杂志。

Bibliometric Analysis of Off-label Use in Domestic and Foreign

OBJECTIVE:To conduct bibliometric analysis of off-label use in domestic and foreign. METHODS:Retrieved from CNKI,Wanfang database,VIP,PubMed,Embase and Web of Science during Jan. 1991(in foreign)or Jan. 2007(in domestic)to Dec. 2018,related literatures of off-label use were collected. General information(publication numbers distribution, journals distribution),article cooperation(core researchers,research content)and keywords of domestic and foreign literatures were analyzed and summarized. RESULTS:A total of 1 647 domestic and 4 418 foreign literatures were retrieved,including 1 570 domestic and 4 238 foreign valid literatures. Publications increased over the past decade,with the largest number of domestic and foreign publication numbers in 2017(355 in domestic and 465 in foreign). The most published domestic and foreign journals were China Pharmacy (105 literatures) and European Journal of Clinical Pharmacology (51 literatures). The core researchers in domestic and foreign were Li Youping and de la Torre JC. The contents of domestic researches included off-label use policy, current situation of off-label use in children,off-label use in ophthalmology,off-label use of Chinese patent medicine,etc. The contents of foreign researches included off-label use in antiviral drugs,off-label use in special population(children,alcoholic dependence patients,etc.). Off-label use,rational drug use and drug instructions as well as human,off-label use and article were the top 3 keywords in domestic and foreign literatures,respectively. CONCLUSIONS:Off-label use research at home and abroad is increasing year by year. Research teams carry out co-operations actively. Bibliometric methods can help researchers broaden research directions,track research hotspots and select contributing journals.