中西医结合长疗程治疗强直性脊柱炎的临床观察

目的：研究控制疾病进展、缩短疗程，减少致残的中西医结合治疗强直性脊柱炎的新疗法，方法：选择确诊的强直性脊柱炎219例做为研究对象，追踪观察2年。治疗组（A组）坚持中西医结合治疗10个月以上者106例，西药对照组（B组）48例，非甾体抗炎镇痛药对照组（C组）34例。结果：（1）近期疗效；A组早效率为73．58％（78／106例），总有效率为96．23％；B组显效率为47．92％（23／48例），总有效率为87．50％；C组显效率为5．88％（2／34例）总有效率为41．18％；A组与B组比较差异有显著性（X^2=10.58,P<0.01)，A组优于B组；A组与C组比较差异有显著性x^2=67.76,P<0.01),A组优于C组。（2）两年后随访：A组有效率复发率为18．37％（9／49例），B组有效率复发率为30．43％（7／23例，A组与B组比较差异无显著性（X^2=1．32，P＞0．05），C组有效者复发率为66．67％（8／12例），A组与C组比较差异有显著性（X^2=11．19，P＜0．01），C组复发率高于A组。结论：中西医结合长疗程治疗强直性脊柱炎集中、西两医优点，其方法可行，疗效可靠，副作用较少，具有推广应用价值。

Clinical Study on Long-Term Treatment of Ankylosing Spondylitis with Integrated Traditional Chinese and Western Medicine

OBJECTIVE: To seek for the new method of integrated traditional Chinese and western medical treatment (TCM-WM) for ankylosing spondylitis (AS) to control the disease development, shorten the therapeutic course and reduce disability rate. METHODS: Patients of AS enrolled in this study were 106 patients in group A, who were persistently treated with TCM-WM for over 10 months, 48 patients in group B treated with western medicine and 34 in group C treated with non-steroidal anti-inflammatory and analgesic agents. They were followed-up for 2 years. RESULTS: (1) Short-term effect: the markedly effective rate in the three groups was 73.58%, 47.92% and 5.88% respectively, and the total effective rate was 96.23%, 87.50% and 41.18% respectively. The comparisons of group A to group B and C showed significant difference, the effect in group A was superior to that in group B and group C (chi 2 = 10.58, P < 0.01 and chi 2 = 67.76, P < 0.01 respectively). (2) Results of 2-year follow-up: the recurrence rate in group A was 18.37% (9/49), it was insignificantly different from that in group B (7/23 = 30.43%, chi 2 = 1.32, P > 0.05), but significantly different from that in group C (8/12 = 66.67%, chi 2 = 11.19, P < 0.01). CONCLUSION: Long-term TCM-WM therapy, which concentrated on the advantages of traditional Chinese and western medicine, was a practical method in treating AS with reliable effect, few side-reaction, therefore, is worth spreading.