Impact of Diabetes Mellitus on Intravascular Ultrasound‐Guided Provisional Stenting in Coronary Bifurcation Lesions J‐REVERSE Sub‐Study |
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| Authors: | Masahiro Yamawaki M.D. Daisuke Terashita M.D. Hachidai Takahashi M.D. Toshiro Shinke M.D. Kenichi Fujii M.D. Yoshihisa Shimada M.D. Yoshihiro Takeda M.D. Shinichiro Yamada M.D. Yoshihisa Kinoshita M.D. Yoshinobu Murasato M.D. |
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| Affiliation: | 1. Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Yokohama, Japan;2. Department of Cardiology, Kobe University Graduate School of Medicine, Kobe, Japan;3. Department of Cardiology, Hyogo Medical University, Nishinomiya, Japan;4. Department of Cardiology, Shiroyama Hospital, Habikino, Japan;5. Department of Cardiology, Rinku General Hospital, Izumi‐Sano, Japan;6. Department of Cardiology, North Harima Medical Center, Ono, Japan;7. Department of Cardiology, Toyohashi Heart Center, Toyohashi, Japan;8. Department of Cardiology, Kyushu Medical Center, Fukuoka, Japan |
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| Abstract: | Objective To investigate the impact of diabetes mellitus (DM) on provisional coronary bifurcation stenting under the complete guidance of intravascular‐ultrasound (IVUS). Background The efficacy of such intervention has not yet been fully elucidated in the DM patients. Methods A total of 100 DM and 139 non‐DM patients in a prospective multi‐center registry of IVUS‐guided bifurcation stenting were compared in angiographic results at 9 months. Vessel and luminal changes during the intervention were analyzed using the IVUS. Vascular healing at the follow‐up was also investigated in 23 lesions in each group using optical coherence tomography (OCT). Results No difference was detected regarding baseline reference vessel diameter and minimum lumen diameter in proximal main vessel (MV), distal MV, and side branch (SB). The rate of everolimus‐eluting stent use (78.4% vs. 78.3%), final kissing inflation (60.1% vs. 49.0%), and conversion to 2‐stent strategy (2.9% vs. 2.8%) were also similar. In the DM group, late loss was greater in proximal MV (DM 0.23 ± 0.29 vs. non‐DM 0.16 ± 0.24 mm, P < 0.05) and SB (0.04 ± 0.49 vs. ?0.08 ± 0.35 mm, P < 0.05). Smaller vessel area restricted stent expansion in the proximal MV (6.18 ± 1.67 vs. 6.72 ± 2.07 mm2, P < 0.05). More inhomogeneous neointimal coverage (unevenness score, 1.90 ± 0.33 vs. 1.72 ± 0.29, P < 0.05) and more frequent thrombus attachment (26% vs. 4%, P < 0.05) were documented in the proximal MV at 9‐month follow‐up OCT. Conclusions Despite IVUS optimization for coronary bifurcation, DM is potentially associated with smaller luminal gain, higher late‐loss, and inhomogeneous vascular healing with frequent thrombus attachment in the proximal MV. |
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