Cerebral mucormycosis: pathogenesis of the disease; description of the fungus,Rhizopus oryzae,isolated from a fatal case |
| |
| Authors: | BAUER H AJELLO L ADAMS E HERNANDEZ D U |
| |
| Affiliation: | 1. Emory University, Georgia USA;2. Department of Health, Education and Welfare, Bethesda, Maryland USA;1. Department of Agricultural Biotechnology, Anand Agricultural University (AAU), Anand, 388 110, India;2. Division of Plant Improvement, Propagation and Pest Management, Central Arid Zone Research Institute (CAZRI), Jodhpur, 342 003, India;3. Department of Genetics and Plant Breeding, CCS Haryana Agricultural University (CCSHAU), Hisar, 125 004, India;4. Department of Biotechnology and Molecular Biology, CCS Haryana Agricultural University (CCSHAU), Hisar, 125 004, India;1. Departamento de Promoción de la Salud, Universidade Federal da Paraíba, João Pessoa, Brasil;2. Programa de Posgrado en Ciencias de la Salud, Universidade Federal do Rio Grande do Norte, Natal, Brasil;3. CIBER de Epidemiología y Salud Pública (CIBERESP), España;4. Observatorio de Salud y Medio Ambiente de Andalucía (OSMAN), Escuela Andaluza de Salud Pública, Granada, España;5. Departamento de Estadística, Programa de Posgrado en Modelos de Decisión y Salud, Universidade Federal da Paraíba, João Pessoa, Brasil;6. Departamento de Nutrición, Universidade Federal da Paraíba, João Pessoa, Brasil;7. Departamento de Odontología, Universidade Federal do Rio Grande do Norte, Natal, Brasil;8. Departamento de Enfermería, Universidad de Sevilla, Sevilla, España;1. Monash Infectious Diseases, Monash Health, Clayton, Victoria, Australia;2. Department of Anatomical Pathology, Monash Health, Clayton, Victoria, Australia;3. Department of Microbiology, Monash Health, Clayton, Victoria, Australia;4. National Mycology Reference Centre, SA Pathology, Adelaide, South Australia, Australia;5. Department of Plastic & Reconstructive Surgery, Monash Health (Dandenong Hospital), Dandenong, Victoria, Australia;6. Department of Microbiology, Monash University, Clayton, Victoria, Australia |
| |
| Abstract: | Rhizopus oryzae has been isolated and identified as the infectious agent in one of two diabetic patients dying of cerebral mucormycosis.To our knowledge this rare and fatal complication of diabetes mellitus has never been diagnosed prior to the patient's death.The clinical and autopsy findings of this fungus disease in our own and previously reported cases are reviewed. The paranasal sinuses are suggested as a possible portal of entry of the infection and problems of pathogenesis are discussed.From this study emerges a syndrome consisting of uncontrolled diabetes mellitus associated with ophthalmoplegia, signs of meningoencephalitis and, possibly, sinusitis. These characteristic manifestations may permit an antemortem diagnosis of this disorder. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
