| 新月弯孢霉对重楼皂苷的生物转化 |
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| 引用本文： | 冯冰,马百平,康利平,熊呈琦,王升启.新月弯孢霉对重楼皂苷的生物转化[J].中草药,2005,36(7):978-982. |
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| 作者姓名： | 冯冰 马百平 康利平 熊呈琦 王升启 |
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| 作者单位： | 军事医学科学院放射医学研究所,北京,100850 |
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| 摘 要： | 目的寻找选择性水解甾体皂苷C-3位糖链末端糖基的微生物,同时制备甾体皂苷的去糖基衍生物。方法利用新月弯孢霉(3.438 1)培养,对C-3位有双糖基结构的甾体皂苷类化合物重楼皂苷Ⅴ(化合物Ⅰ)、重楼皂苷Ⅵ(化合物Ⅱ)进行生物转化;用反相C18开放柱进行转化产物的分离纯化,波谱方法鉴定其结构。结果新月弯孢霉(3.438 1)均能将化合物Ⅰ和化合物ⅡC-3位糖链末端的鼠李糖水解,转化为单糖基皂苷,转化产物分别鉴定为薯蓣皂苷元-3-O-β-D-吡喃葡萄糖苷,即延龄草苷(trillin,化合物Ⅲ)和偏诺皂苷元-3-O-β-D-吡喃葡萄糖苷(化合物Ⅳ)。结论首次发现新月弯孢霉(3.438 1)对重楼皂苷Ⅴ和重楼皂苷ⅥC-3位糖链的末端鼠李糖具有较强的水解能力。
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| 关 键 词： | 新月弯孢霉 重楼皂苷Ⅴ 重楼皂苷Ⅵ 生物转化 |
| 文章编号： | 0253-2670(2005)07-0978-05 |
| 收稿时间： | 2004/9/20 0:00:00 |
Biotransformation of polyphyllins by Curvularia lunata fermentation |
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| FENG Bing,MA Bai-ping,KANG Li-ping,XIONG Cheng-qi and WANG Sheng-qi.Biotransformation of polyphyllins by Curvularia lunata fermentation[J].Chinese Traditional and Herbal Drugs,2005,36(7):978-982. |
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| Authors: | FENG Bing MA Bai-ping KANG Li-ping XIONG Cheng-qi and WANG Sheng-qi |
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| Institution: | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China;Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China;Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China;Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China;Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China |
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| Abstract: | |
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| Keywords: | Curvularia lunata(Wald )Boed polyphyllin V polyphyllin VI hiotransformation |
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