Diagnostic performance of fluorine-18-dihydroxyphenylalanine positron emission tomography in diagnosing and localizing the focal form of congenital hyperinsulinism: a meta-analysis |
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Authors: | Giorgio Treglia Paoletta Mirk Alessandro Giordano Vittoria Rufini |
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Institution: | 1. Institute of Nuclear Medicine, Catholic University of the Sacred Heart, Largo Gemelli, 8, Rome, 00168, Italy 2. Institute of Radiology, Catholic University of the Sacred Heart, Rome, Italy
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Abstract: | Introduction We performed a meta-analysis on published data on the diagnostic performance of fluorine-18 dihydroxyphenylalanine (18F-DOPA) positron emission tomography (PET) in diagnosing and localizing focal congenital hyperinsulinism (CHI). Materials and methods A comprehensive computer literature search of studies published up to 31 January 2012 regarding 18F-DOPA PET or PET/CT in patients with CHI was performed. Pooled sensitivity and specificity, area under the ROC curve and diagnostic odds ratio (DOR) of 18F-DOPA PET or PET/CT in diagnosing focal CHI were calculated. The localization accuracy of focal CHI was also estimated. Seven studies comprising 195 CHI patients were included. Results The pooled sensitivity and specificity of 18F-DOPA PET or PET/CT in differentiating between focal and diffuse CHI were 89% (95% confidence interval CI]:81–95%) and 98% (95% CI:89–100%), respectively. The DOR was 74.5 (95% CI:18–307). The area under the ROC curve was 0.95. The pooled accuracy of these functional imaging methods in localizing focal CHI was 80% (95% CI:71–88%). Discussion In CHI patients, 18F-DOPA PET or PET/CT demonstrated high sensitivity and specificity in differentiating between focal and diffuse CHI. 18F-DOPA PET or PET/CT are accurate methods of localizing focal CHI. Nevertheless, possible sources of false-negative results for focal CHI should be kept in mind. |
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