Cerebral microbleeds: a guide to detection and clinical relevance in different disease settings |
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Authors: | Andreas Charidimou Anant Krishnan David J. Werring H. Rolf Jäger |
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Affiliation: | 1. Stroke Research Group, UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK 2. Lysholm Department of Neuroradiology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK 3. Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK 4. UCL Institute of Neurology. The National Hospital for Neurology and Neurosurgery, University College Hospital (UCH), 8-11 Queen Square, Box 65, London, WC1 N3BG, UK
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Abstract: | Cerebral microbleeds have emerged as an important new imaging marker of cerebral small vessel disease. With the development of MRI techniques that are exquisitely sensitive to paramagnetic blood products, such as T2*-weighted gradient-recalled echo and susceptibility-weighted sequences, microbleeds have been detected in ever-increasing numbers of patients in stroke and cognitive clinics, as well as in healthy older people and in a variety of other rarer diseases and syndromes. Detection of cerebral microbleeds has clinical implications with respect to the diagnosis of the underlying small vessel disease, the safety of antithrombotic use, and the risk of symptomatic intracerebral haemorrhage, cognitive impairment and dementia. This article provides a guide to the detection and clinical relevance of cerebral microbleeds in different conditions based on a comprehensive review of the literature and own findings in research and clinical practice. |
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