| Cathepsin D在胃癌组织中的表达及其临床意义 |
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| 引用本文： | 杨文君,俞友娟,陈维. Cathepsin D在胃癌组织中的表达及其临床意义[J]. 杭州医学高等专科学校学报, 2003, 24(1): 10-11 |
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| 作者姓名： | 杨文君 俞友娟 陈维 |
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| 作者单位： | 杭州师范学院医学院附属医院病理科 浙江杭州310015(杨文君，俞友娟)，杭州师范学院医学院附属医院病理科 浙江杭州310015(陈维) |
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| 摘 要： | 目的 探讨CathepsinD在早、中晚期胃癌中的表达及其临床意义。方法 应用免疫组织化学 (ABC法 )对 70例胃癌标本进行CathepsinD蛋白的检测。结果 早期胃癌CathepsinD表达率为 6 0 % (12 / 2 0 ) ,中晚期无淋巴结转移胃癌为 6 5 % (13/ 2 0 ) ,中晚期有淋巴结转移胃癌为 86 .6 7% (2 6 / 30 ) ,后两者在表达率上有显著性差异 (P <0 .0 5 )。结论 CathepsinD的表达水平可作为胃癌预后的判断指标之一。
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| 关 键 词： | 胃癌 CathepsinD 免疫组织化学 |
| 文章编号： | 1008-4894(2003)01-0010-02 |
| 修稿时间： | 2002-11-09 |
Different expression of Cathepsin D and the clinical significance in gastric carcinoma |
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| YANG Wen|Jun,YU You|juan,CHEN Wei. Different expression of Cathepsin D and the clinical significance in gastric carcinoma[J]. Journal of Hangzhou Medical College, 2003, 24(1): 10-11 |
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| Authors: | YANG Wen|Jun YU You|juan CHEN Wei |
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| Abstract: | Objective Objective To study the expression of Cathepsin D in early and advanced stages of gastric carcinoma and its clinical significance.Methods Expressions of Cathepsin D protein were detected in 70 specimens with gastric cancers by immunohistochemistry (ABC method).Results The expression rates of Cathepsin D were 60% (12/20) in the early stage, 65% (13/20) in the advanced stage without lymph node metastasis, and 86.7% (26/30) in the advanced stage with lymph node metastasis of gastric cancers respectively. Positive expression rate of Cathepsin D was correlated with clinical stages and lymph node metastasis of gastric cancer ($P$<0.05).Conclusion Cathepsin D protein can be considered as one of indicators for evaluating the prognosis of gastric cancer. |
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| Keywords: | gastric cancer Cathepsin D Immunohistochemistry |
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