肿瘤坏死因子、更生霉素和干扰素-γ联合应用对人卵巢癌裸鼠模型的协同作用

目的：研究联合应用肿瘤坏死因子（TNF）、干扰素－γ（IFN－γ）和更生霉素（KSM）对人卵巢癌裸鼠模型的协同作用。方法：将荷瘤裸鼠随机分成4组，分别用生理盐水、KSM、TNF＋IFN－γ、KSM＋TNF＋IFN－γ处理，观察肿瘤生长情况。结果：各组肿瘤相对体积比较，KSM组和KSM＋TNF＋IFN－γ组与对照组比较，差异有显著性（P＜0．05和P＜0．01）；TNF＋IFN－γ组与对照组比较，差异无显著性（P＞0．05），而KSM＋TNF＋IFN－γ组与KSM组比较，差异有显著性（P＜0．05）。结论：KSM与TNF、IFN－γ联合应用有协同抗卵巢癌细胞系3AO的作用，为临床应用提供了理论依据。

Synergistic action by combined application with TNF,KSM and IFN-γ in nude mice model of human ovarian cancer

To study on the synergistic effects of combined application with TNF, IFN-γ and KSM to nude mice model of human ovarian cancer. Methods: Sixteen nude mice models of human ovarian cancer were treated with physiological saline(control group) KSM, TNF + IFN-γ and KSM + TNF + IFN-γ, and their effects were compared. Results: The relative tumor volumes of the KSM group and KSM + TNF + IFN-γ group were significantly lower than that of control group (P< 0. 05 and P< 0. 01, respectively ). In comparison of the relative tumor volume between TNF+ IFN -γ group and control group, there was no significant difference (P>0. 05), but there was Significant difference between the KSM + TNF + IFN-γ group and the KSM group (P< 0. 05 ). Conclusions: The results suggest that the combined application with TNF, IFN-γ and KSM may have synergistic action against ovarian cancer cell line 3AO. This suggestion may be an important theoretical accordance for the clinical use.