阿魏酸钠治疗糖尿病周围神经病变的疗效观察

目的观察阿魏酸钠治疗糖尿病周围神经病变的疗效。方法将75例糖尿病周围神经病变患者常规给予基础治疗,糖尿病教育、运动及糖尿病饮食,并运用口服药物和胰岛素严格控制血糖,原治疗措施不变,停用其它抗凝剂、扩血管药及营养神经药物。随机分成治疗组45例,给予阿魏酸钠0.3g静脉滴注1次/d,共20d,对照组30例给予维生素B1和维生素B12,比较其疗效。结果治疗组症状、体征的改善与对照组相比差异有统计学意义(P<0.05);肌电图检测显示神经传导速度,治疗组治疗前与治疗后有明显变化(P<0.05),明显高于对照组。结论阿魏酸钠有明显改善糖尿病周围神经病变的疗效。

Observation about the clinical curative effect of sodium ferulate in treating diabetic peripheral neuropathy

Objective To observe the clinical curative effect of sodium ferulate in treating diabetic peripheral neuropathy.Methods 75 inpatients with diabetic peripheral neuropathy were given conventional treatment,diabetes education,sports and diabetic diet with strict control of blood glucose.At the same time,their original treatment were not changed without other anticoagulants,vasodilators and neurotrophic drugs.The 75 inpatients with diabetic peripheral neuropathy were selected and randomly divided into 2 groups : treatment group(n=45) and control group(n=30).The treatment group were given intravenously 0.3 sodium ferulate per day for 20 days,and the control group were given a daily intramuscular injection of vitamin B1 10mg and vitamin B12 0.5mg for 20 days.At last we had a comparison of the therapeutic effect.Results The symptoms and signs of the treatment group than of the control group were improved significantly different;EMG nerve test showed that the treatment group before and after treatment had significant changes in conduction velocity than the control group improved significantly.Conclusion It is of exact curative to treat diabetic peripheral neuropathy with sodium ferulate.