| 促红细胞生成素对兔心肌缺血再灌注损伤的保护作用 |
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| 引用本文： | 李公任,速晓华,李刚,张渝华.促红细胞生成素对兔心肌缺血再灌注损伤的保护作用[J].四川医学,2012,33(4):589-591. |
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| 作者姓名： | 李公任 速晓华 李刚 张渝华 |
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| 作者单位： | 成都军区总医院心血管内科,四川成都,610083 |
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| 摘 要： | 目的探讨促红细胞生成素(erythropoietin,Epo)对兔心肌缺血再灌注的保护作用。方法建立兔心肌缺血再灌注损伤模型,选用新西兰兔30只随机分为对照组、缺血组、Epo治疗组,检测血浆丙二醛(MDA)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、肌钙蛋白T(cTnT)和心脏组织匀浆超氧化物歧化酶(SOD)、白介素-6(IL-6)变化。结果 Epo治疗组血浆MDA、CK、CK-MB、cTnT水平较缺血组显著下降(P<0.05);心脏组织匀浆SOD显著升高、IL-6显著降低(P<0.05)。结论 Epo对兔心肌缺血再灌注损伤具有保护作用,这种作用可能与提高心脏组织中SOD水平,降低心脏组织中IL-6水平有关。
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| 关 键 词： | 心脏损伤 失血性休克 促红细胞生成素 |
Protective effect of erythropoietin on heart ischemia reperfusion injury in rabbits. |
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| Institution: | LI Gong-ren,SU Xiao-hua,LI Gang,et al.General Hospital of Chengdu Military Command,Chengdu,Sichuan 610083,China |
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| Abstract: | Objective To study the protective effect of erythropoietin on heart ischemia /reperfusion(I/R)injury in rabbits.Methods The model was made by ligating the left desceding coronary artery for 45 minutes and reperfusing for 1 hour in rabbits.30 rabbits were divided into control group,ischemia group and Epo group.Epo was used on the rabbits at the beginning of reperfusion.Plasma MDA,CK,CK-MB,cTnT and tissue SOD,IL-6 were observed.Results Plasma MDA,CK,CK-MB,cTnT and tissue IL-6 of Epo group were significantly lower than those ischemia group.SOD in heart tissue was significantly higher.Conclusion Our results indicate that Epo has a protective effect on heart ischemia/reperfusion injury in rabbits because it can increase SOD in heart tissue,decrease IL-6 in heart tissue. |
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| Keywords: | heart injury ischemia /reperfusion injury erythropoietin |
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