慢性阻塞性肺疾病微循环机能、内皮素、SOD酶改变的临床研究

目的探讨COPD与微循环,内皮素分泌水平,SOD酶活性变化的关系,旨在为COPD的早期发现,早期防治提供实验依据。方法已确诊的46例COPD患者为观察组,正常健康体检人员40例为对照组,分别对其微循环各项指标(全血粘度,血浆粘度,血球压积,红细胞沉降率),ET以及SOD进行检测,结果以POMS软件做FLSD检验,P<0.05为差异有统计学意义。结果 COPD患者上述各项指标与对照组比较差异有统计学意义,P<0.05。结论 COPD与微循环各项指标的异常,内皮素分泌增加和低水平的SOD酶活性密切相关,且异常程度与COPD的严重程度呈正比。

The clinical study of the changing of microcirculation and plasma ET, SOD in chronic obstructive pulmonary disease

Objective To open out the relationship of COPD and the changing of the microcirculation and plasma ET,SOD,for provide the according as experiment to inchoate prevent and treatment.Methods 46 objects whose have diagnosed COPD as observer group and 40 objects whose health checked up as control group,the indexes of the WBV、PV、HCT、ERS and ET,SOD were measured.All the statistical analysis of the mean indexes were evaluate with FLSD test,P<0.05 being considered significant.Results Above indexes of COPD have notably significant,compared with the control group,P<0.05.ConclusionThere have closed correlation between COPD and abnormal changing of indexes as microcirculation and plasma ET,SOD,and they showed the direct proportion to abnormal degree indexes and severity degree to COPD.