妊娠期肝内胆汁淤积症与围产儿预后的临床分析

目的探讨妊娠期肝内胆汁淤积症(ICP)对围产儿预后的影响。方法 2009年10月～2011年3月住院分娩的ICP孕妇145例为ICP组,设同期分娩145例正常孕妇为对照组,比较两组间胎儿宫内窘迫、羊水粪染、新生儿窒息、早产儿、新生儿肺炎、围产儿死亡的发生率。结果 ICP组胎儿宫内窘迫、羊水粪染、新生儿窒息、新生儿肺炎的发生率与对照组相差比较差异有统计学意义(P<0.05)。结论 ICP可导致胎儿宫内窘迫、羊水粪染、新生儿窒息、早产,早发现、早诊断以及果断处理,适时终止妊娠,可以降低围产儿病死率。

Clinical analysis of intrahepatic cholestasis of pregnancy and perinatal prognosis

Objective To investigate effect of the intrahepatic cholestasis of pregnancy(ICP) on perinatal prognosis.Methods 145 cases of ICP pregnant women giving birth in hospital between October 2009 and March 2011 were taken as ICP group.Another 145 cases of cases of normal pregnant women during the same period were taken as control group for comparisons between fetal distress,meconium-stained amniotic fluid,neonatal asphyxia,preterm children,neonatal pneumonia,and the incidence of perinatal death.Results The differences of fetal distress,meconium-stained amniotic fluid,neonatal asphyxia,and the incidence of neonatal pneumonia between ICP group and the control group were significant(P<0.05).Conclusion ICP can lead to fetal distress,meconium-stained amniotic fluid,neonatal asphyxia and premature birth.Early detection,diagnosis,treatment and timely termination of pregnancy can reduce perinatal mortality.